CD4 T Cells Mediate Killing during Persistent Gammaherpesvirus 68 Infection
CD4 T Cells Mediate Killing during Persistent Gammaherpesvirus 68 Infection
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DOI：
10.1128/jvi.02240-08
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发表时间：
2009-05-01
影响因子：
5.4
通讯作者：
Flano, Emilio
中科院分区：
文献类型：
--
作者：
Stuller, Kathleen A.;Flano, Emilio
CD4 T cells are critical for the control of gammaherpesvirus persistence, but their direct effector mechanisms of virus control in vivo are still poorly understood. In this study, we use murine gammaherpesvirus 68 (gamma HV68) in in vitro and in vivo cytotoxicity assays to show CD4-dependent killing of gamma HV68-loaded cells in mice persistently infected with gamma HV68. Our results underscore the cytotoxic capacity of CD4 T cells during gamma HV68 persistence.
