Anchoring 20(R)-Ginsenoside Rg3 onto Cellulose Nanocrystals To Increase the Hydroxyl Radical Scavenging Activity
Anchoring 20(R)-Ginsenoside Rg3 onto Cellulose Nanocrystals To Increase the Hydroxyl Radical Scavenging Activity
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DOI：
10.1021/acssuschemeng.6b02996
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发表时间：
2017-08
影响因子：
8.4
通讯作者：
Chunxia Tang;Yulong Wang;Yunduo Long;Xingye An;Jing Shen;Y. Ni
中科院分区：
文献类型：
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作者：
Chunxia Tang;Yulong Wang;Yunduo Long;Xingye An;Jing Shen;Y. Ni
纤维素纳米晶体（CNCs）作为生物活性分子的载体，表现出很有吸引力的特性，包括其大的表面积、电荷特性和丰富的表面羟基等。在这项研究中，我们使用CNCs作为疏水药物20（R）-Rg 3（这里简称为20（R）-Rg 3）的载体，以提高其在水体系中的生物利用度、分散性和抗氧化活性。制备了CNC/20（R）-Rg 3纳米复合材料，并用透射电镜、傅里叶变换红外光谱和X射线衍射对其进行了表征。20（R）-Rg 3的粒径在8-22 nm范围内。2-脱氧核糖氧化法和水杨酸羟基化法体外清除羟自由基实验表明，CNC/20（R）-Rg 3纳米复合材料的抗氧化活性（33.58%和48.62%）明显高于不含CNC的20（R）-Rg 3、水分散的20（R）-Rg 3和CNC。
Cellulose nanocrystals (CNCs) exhibit attractive properties as carriers for bioactive molecules, including their large surface area, charge characteristics, and abundant surface hydroxyl groups, among others. In this study, we used CNCs as carriers for a hydrophobic drug, 20(R)-ginsenoside Rg3 (here abbreviated as 20(R)-Rg3), to improve its bioavailability, dispersity, and antioxidation activity in an aqueous system. The CNC/20(R)-Rg3 nanocomposites were fabricated and then characterized by transmission electron microscopy, Fourier transform IR spectroscopy, and X-ray diffraction. The particle size of 20(R)-Rg3 was in the range of 8–22 nm. In vitro hydroxyl radical scavenging by the 2-deoxyribose oxidation method and the salicylic acid hydroxylation method showed that the CNC/20(R)-Rg3 nanocomposites had much higher antioxidation activity (33.58% and 48.62%) than CNC-free 20(R)-Rg3, water-dispersed 20(R)-Rg3, and CNCs.