Differential serum lipid distribution in IPAH and CHD-PAH patients
Differential serum lipid distribution in IPAH and CHD-PAH patients
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IPAH 和 CHD-PAH 患者血脂分布差异
DOI：
10.1016/j.rmed.2021.106711
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发表时间：
2022-01-01
影响因子：
4.3
通讯作者：
Li, Jiang
中科院分区：
文献类型：
--
作者：
Chen, Jingyuan;Rathinasabapathy, Anandharajan;Li, Jiang
肺动脉高压（PAH）中脂质稳态失调。血清高、低密度脂蛋白胆固醇（HDL-C和LDL-C）的降低与PAH预后不良显著相关。然而，没有研究调查脂质在各种多环芳烃亚型中的差异分布。我们在这项回顾性研究中招募了190例患者，其中包括20例无PAH的先天性心脏病（chd -non -PAH）， 101例PAH合并先天性心脏病（CHD-PAH）， 69例特发性PAH （IPAH）和81例健康对照。检测肝肾功能、血脂、c反应蛋白、n端脑利钠肽前体（NT-proBNP）、超声心动图、右心导管检查、6分钟步行距离（6-MWD）等实验室指标。所有类型的胆固醇，包括HDL-C， ldl和总胆固醇（CHOL）在IPAH患者中与右心功能相关的显著降低。尽管LDL-C和CHOL在CHD-PAH患者中较低，但它们与疾病严重程度或心力衰竭无关。因此，我们得出结论，IPAH和冠心病- pah患者表现出不同的血脂分布模式。
Lipid homeostasis is dysregulated in pulmonary arterial hypertension (PAH). A decrease in serum high-and low density lipoprotein cholesterol (HDL-C and LDL-C) is significantly associated with the worse prognosis of PAH. However, no study has investigated the differential distribution of lipids in various PAH subtypes. We enrolled 190 patients in this retrospective study, which includes 20 patients with congenital heart disease without PAH (CHD-nonPAH), 101 patients with PAH associated with congenital heart disease (CHD-PAH), 69 patients with idiopathic PAH (IPAH) and 81 healthy controls. Laboratory parameters such as liver and renal function, serum lipids, C-reactive protein, N-terminal pro-brain natriuretic peptide (NT-proBNP), echocardiography, right heart catheterization and 6-min walk distance (6-MWD) were performed. All types of cholesterol including HDL-C, LDLC and total cholesterol (CHOL) were significantly lower in IPAH patients in association with right heart function. Although LDL-C and CHOL were lower in CHD-PAH, they were not associated with disease severity or heart failure. Thus, we conclude that IPAH and CHD-PAH patients exhibited a differential distribution pattern of serum lipids.