Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study.
Right ventricular structure is associated with the risk of heart failure and cardiovascular death: the Multi-Ethnic Study of Atherosclerosis (MESA)--right ventricle study.
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DOI：
10.1161/circulationaha.112.095216
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发表时间：
2012-10-02
期刊：
影响因子：
37.8
通讯作者：
Bluemke DA
中科院分区：
文献类型：
--
作者：
Kawut SM;Barr RG;Lima JA;Praestgaard A;Johnson WC;Chahal H;Ogunyankin KO;Bristow MR;Kizer JR;Tandri H;Bluemke DA
右心室形态学的改变与心肺疾病的发病率和死亡率有关。我们在基线无临床心血管疾病的人群为基础的多种族样本中研究了异常左心室结构和功能与心力衰竭（HF）或心血管死亡风险的关系。动脉粥样硬化多种族研究（MESA）在2000-2002年间对5098名参与者进行了心脏磁共振成像（MRI），并随访了心力衰竭和心血管死亡事件（“死亡”），直到2008年1月。RV的体积和质量可用于4204名参与者。研究样本（N = 4144），年龄61.4±10.1岁，男性占47.6%。经人口统计学、体重指数、教育程度、c反应蛋白水平、高血压和吸烟状况调整后，右心室肥大（右心室质量增加）的存在与心力衰竭或死亡风险增加一倍以上相关（HR = 2.52, 95%CI 1.55-4.10, p < 0.001），左心室质量在平均值或更低时，风险增加一倍（或更多）（相互作用p = 0.05）。在基线时无临床心血管疾病的多民族人群中，右心室肥大与心力衰竭或死亡风险相关。
Changes in right ventricular (RV) morphology are associated with morbidity and mortality in heart and lung disease. We examined the association of abnormal RV structure and function with the risk of heart failure (HF) or cardiovascular death in a population-based multiethnic sample free of clinical cardiovascular disease at baseline. The Multi-Ethnic Study of Atherosclerosis (MESA) performed cardiac magnetic resonance imaging (MRI) on 5098 participants between 2000–2002 with follow-up for incident heart failure and cardiovascular death (“death”) until January 2008. RV volumes and mass were available for 4204 participants. The study sample (N = 4,144) was 61.4 ± 10.1 years old and 47.6 % male. The presence of RV hypertrophy (increased RV mass) was associated with a more than twice the risk of heart failure or death after adjustment for demographics, body mass index, education, C-reactive protein level, hypertension, and smoking status (HR = 2.52, 95%CI 1.55–4.10, p < 0.001) and a doubling of risk (or more) with left ventricular mass at the mean value or lower (p for interaction = 0.05). RV hypertrophy was associated with the risk of heart failure or death in a multi-ethnic population free of clinical cardiovascular disease at baseline.