BIOLOGICAL IMPLICATIONS OF HLA-DR EXPRESSION IN TUMORS
BIOLOGICAL IMPLICATIONS OF HLA-DR EXPRESSION IN TUMORS
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DOI：
10.1111/j.1365-3083.1995.tb03584.x
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发表时间：
1995-04-01
影响因子：
3.7
通讯作者：
GARRIDO, F
中科院分区：
文献类型：
--
作者：
CABRERA, T;RUIZCABELLO, F;GARRIDO, F
与 HLA I 类分子更广泛的表达相比，HLA-DR 抗原显示出有限的组织分布。这种组成型表达是由明确的机制进行遗传控制的。此外，多种细胞因子可以通过不同的分子遗传事件诱导DR抗原表达，将DR阴性上皮细胞转化为阳性细胞。在这篇综述中，我们分析了DR表达异常的两种主要病理情况：自身免疫性疾病和肿瘤发展。我们假设，转变为 DR 阳性可能在两种临床情况下产生两种相反的效果：（1）对于与良好预后相关的肿瘤有用的效果； (2) 自身免疫性疾病中有害的一种，会增加组织损伤。
HLA-DR antigens show restricted tissue distribution in comparison with the more extensive expression of HLA class I molecules. This constitutive expression is genetically controlled by well-defined mechanisms. In addition, DR antigen expression can be induced by a variety of cytokines through different molecular genetic events that convert DR-negative epithelia into positive cells. In this review we analyse the two major pathological situations in which abnormal DR expression occurs: autoimmune diseases and tumour development. We hypothesize that conversion to DR-positivity may produce two opposite effects in both clinical situations: (1) a useful one in tumours associated with a good prognosis; and (2) a harmful one in autoimmune diseases with increased tissue damage.