Magnetic Resonance Imaging with laser polarized 129Xe
Magnetic Resonance Imaging with laser polarized 129Xe
复制标题
使用激光偏振 129Xe 进行磁共振成像
DOI：
10.1063/1.55021
复制
发表时间：
1998
影响因子：
3.3
通讯作者：
T. Chupp
中科院分区：
文献类型：
--
作者：
S. Swanson;M. Rosen;B. Agranoff;K. Coulter;R. Welsh;T. Chupp
磁共振成像与激光偏振129可用于跟踪血流和灌注组织的各种生物医学应用。被引入肺部的极化氙气溶解在血液中，并被输送到器官，如大脑，在那里它积聚在组织中。光谱学研究结合成像技术已经被用于在大鼠头部产生129的大脑图像。这项工作确定了气相中产生的核极化在运输到大脑中可以成像的过程中幸存下来。增加极化和129 mmHg的输送量将允许临床测量局部血流。
Magnetic Resonance Imaging with laser-polarized 129Xe can be utilized to trace blood flow and perfusion in tissue for a variety of biomedical applications. Polarized xenon gas introduced in to the lungs dissolves in the blood and is transported to organs such as the brain where it accumulates in the tissue. Spectroscopic studies combined with imaging have been used to produce brain images of 129Xe in the rat head. This work establishes that nuclear polarization produced in the gas phases survives transport to the brain where it may be imaged. Increases in polarization and delivered volume of 129Xe will allow clinical measurements of regional blood flow.