Soft lens extended wear affects epithelial barrier function.
Soft lens extended wear affects epithelial barrier function.
复制标题
软镜片长期佩戴会影响上皮屏障功能。
DOI：
10.1016/s0161-6420(98)91237-4
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Suzuki,RM
中科院分区：
文献类型：
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作者：
McNamara,NA;Polse,KA;Fukunaga,SA;Maebori,JS;Suzuki,RM
目的探讨闭眼和软性隐形眼镜延长配戴(SCLEW)对上皮对荧光素(PDC)通透性的影响。设计前瞻性队列研究，配戴1只非接触镜(CL)者参加。干预通过比较非CL受试者上午(Am)和下午(Pm)的测量来评估闭眼对PDC的影响。通过在SCLEW开始前、SCLEW后2、4和12周测量Pdc来确定SCLEW对Pdc的影响。检查上午与下午以及SCLEW前与后测量的MAIN结局指标。结果Pdc的分析使用自然对数(In)。16名非CL佩戴者在上午和下午测量的平均标准差(PDC)无显著差异(−分别为2.56±0.16和−2.69±0.15；P=0.46)。相反，15名受试者在戴镜后2周(−1.73±0.183，P<；0.001)、4周(−1.59±0.188，P<；0.001)和12周(−1.99±0.206，P=0.02)的平均±SE ln(−)显著高于配戴前(2.42±0.159 ln(nm/s))。有趣的是，7名受试者在13周后下午测得的平均±SE(PDC)与他们的平均基线(PDC)相似(−分别为2.62±0.27vs.−2.52±0.243；P=0.54)。进一步分析表明，Pdc在早晨最高，白天下降约12.5%/小时(P<；0.001)。结论无CLS的睡眠对Pdc无明显影响；然而，2周的SCLEW使通透性增加99%，裂隙灯检查未见明显变化。Pdcappear的增加在SCLEW后的早上最大，然后在白天呈指数下降。Pdc的变化是否能预测CL相关性角膜病变还有待进一步研究。
OBJECTIVETo explore the impact of eye closure and soft contact lens extended wear (SCLEW) on epithelial permeability to fluorescein (Pdc).DESIGNA prospective cohort study.PARTICIPANTSThirty-one noncontact lens (CL) wearers participated.INTERVENTIONThe effects of eye closure on Pdcwere evaluated by comparing morning (am) and afternoon (pm) measurements on non-CL subjects. The effects of SCLEW on Pdcwere determined by measuring Pdcbefore beginning SCLEW and then after 2, 4, and 12 weeks of SCLEW.MAIN OUTCOME MEASURESPdcmeasured in the morning versus the afternoon and before versus after SCLEW was examined.RESULTSAnalyses of Pdcwere done using the natural logarithm (In). The mean ± standard error (SE) In(Pdc) measured in the am versus pm on 16 non-CL wearers did not differ significantly (−2.56 ± 0.16 vs. −2.69 ± 0.15, respectively; P = 0.46). In contrast, the mean ± SE ln(Pdc) in 15 subjects after 2 (−1.73 ± 0.183, P < 0.001), 4 (−1.59 ± 0.188, P < 0.001), and 12 weeks (−1.99 ± 0.206, P = 0.02) of SCLEW was substantially greater than that measured before lens wear (−2.42 ± 0.159 ln(nm/sec)). Interestingly, the mean ± SE In(Pdc) measured in the afternoon on seven subjects after 13 weeks of SCLEW was similar to their average baseline In(Pdc) (−2.62 ± 0.27 vs. −2.52 ± 0.243, respectively; P = 0.54). Further analysis showed that Pdcwas highest in the morning and decreased approximately 12.5%/hour (P < 0.001) during the day.CONCLUSIONSSleeping without CLs does not appear to alter Pdc; however, 2 weeks of SCLEW caused a 99% increase in permeability without observable changes by slit-lamp examination. Increases in Pdcappear greatest in the morning after SCLEW and then decrease exponentially during the day. Whether changes in Pdcwill predict CL-associated keratopathy needs further study.