The Role of IL-22 in Viral Infections: Paradigms and Paradoxes.
The Role of IL-22 in Viral Infections: Paradigms and Paradoxes.
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DOI：
10.3389/fimmu.2016.00211
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发表时间：
2016
影响因子：
7.3
通讯作者：
Humphreys IR
中科院分区：
文献类型：
--
作者：
Gimeno Brias S;Stack G;Stacey MA;Redwood AJ;Humphreys IR
白介素 22 (IL-22) 是细胞因子 IL-10 家族的成员。造血细胞表达 IL-22，这种细胞因子通过非造血细胞表达的异二聚体 IL-22 受体发出信号。越来越多的证据表明 IL-22 在细胞增殖、组织保护和再生以及炎症等多种生物功能中发挥作用。近年来，IL-22 在抗病毒免疫反应中的作用已在许多感染模型中得到检验。在此，我们评估了目前对 IL-22 如何决定病毒感染结果的理解，并定义了从这些研究得出的、有时是矛盾的发现中显而易见的常见机制。最后，我们讨论了 IL-22 操作在治疗和预防病毒感染及相关病理中的潜在治疗效用。
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies.