Use of repeat sextant and transition zone biopsies for assessing extent of prostate cancer
Use of repeat sextant and transition zone biopsies for assessing extent of prostate cancer
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DOI：
10.1016/s0022-5347(01)64159-4
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发表时间：
1997-11-01
影响因子：
6.6
通讯作者：
Carter, HB
中科院分区：
文献类型：
--
作者：
Epstein, JI;Walsh, PC;Carter, HB
目的：很少有人知道为什么活检会漏掉某些前列腺癌。在针刺活检诊断为癌症的患者中，重复针刺活检是否能提供预测疾病程度的有用信息也是未知的。 材料和方法：在病理学实验室，我们使用 18 号活检枪对针刺活检（Tie 期）检测到的 193 例根治性前列腺切除术标本进行了六分仪和过渡区针刺活检。过渡区活检本身仅在 2.1% 的病例中呈阳性，表明这种特定活检缺乏用处。尽管所有病例在术前穿刺活检时均发现癌症，但 31% 的患者在重复六分仪过渡区活检时未发现癌症。在多变量分析中（变量包括根治性前列腺切除术肿瘤体积、根治性前列腺切除术肿瘤位置、前列腺大小和根治性前列腺切除术等级），肿瘤体积减少（p
Purpose: Little is known why certain prostate cancers are missed on biopsy. In patients with a needle biopsy diagnosis of cancer it is also unknown whether repeat needle biopsy provides useful information to predict extent of disease.Materials and Methods: In the pathology laboratory we performed sextant and transition zone needle biopsies on 193 radical prostatectomy specimens from men with nonpalpable cancer detected on needle biopsy (stage Tie) using an 18 gauge biopsy gun, Radical prostatectomy specimens were then serially sectioned, totally embedded, mapped and staged.Results: The transition zone biopsy by itself was positive in only 2.1% of cases, demonstrating the lack of-usefulness for this particular biopsy. Despite cancer on preoperative needle biopsy in all cases, 31% showed no cancer on repeat sextant transition zone biopsy. In a multivariate analysis (variables included radical prostatectomy tumor volume, radical prostatectomy tumor location, prostate gland size and radical prostatectomy grade) decreased tumor volume (p