Repeatability and Reproducibility of Manual Choroidal Volume Measurements Using Enhanced Depth Imaging Optical Coherence Tomography
Repeatability and Reproducibility of Manual Choroidal Volume Measurements Using Enhanced Depth Imaging Optical Coherence Tomography
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DOI：
10.1167/iovs.12-9435
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发表时间：
2012-04-01
影响因子：
4.4
通讯作者：
Freeman, William R.
中科院分区：
文献类型：
--
作者：
Chhablani, Jay;Barteselli, Giulio;Freeman, William R.
目的。目的评价增强深度成像(EDI)光谱域光学相干断层扫描(SD-OCT)手动测量脉络膜体积(CV)的可重复性和重复性。方法：前瞻性研究32例(60只眼)眼部脉络膜视网膜病变患者。对每只眼睛进行了31次脉络膜扫描，扫描中心位于中心凹，使用了一种栅格方案。两名蒙面观察员在两次不同的会议上使用内置的自动视网膜分割软件划定了脉络膜边界。观察者对彼此的读数和他们自己之前的读数都是遮盖的。用OCT软件自动定位以中心凹为中心的标准化网格，并记录三个同心环的平均CV值和总CV值。使用一致性相关系数(CCC)评估观察者内测量或观察者间测量之间的一致性。结果：观察者间总体平均变异系数非常高，为0.9956(95%可信区间，0.991-0.9968)。所有三个早期治疗糖尿病视网膜病变研究的CCCS两个年级之间的同心圆环为0.98到0.99(95%CI，0.97~0.98)。同样，两名评分员的观察者内重复性也在0.98到0.99之间。观察者间的重复性系数约为0.42(95%CI，0.34-0.5 mm(3))。结论：在EDI-SD-OCT上使用内置的自动视网膜分割软件进行手动分割的CV测量具有很高的重复性和重复性，且变异范围非常小。(投资眼科VS科学。2012年；53：2274-2280)doi：10.1167/iovs.12-9435
PURPOSE. To evaluate the repeatability and reproducibility of manual choroidal volume (CV) measurements by spectral domain-optical coherence tomography (SD-OCT) using enhanced depth imaging (EDI).METHODS. Sixty eyes of 32 patients with or without any ocular chorioretinal diseases were enrolled prospectively. Thirty-one choroidal scans were performed on each eye, centered at the fovea, using a raster protocol. Two masked observers demarcated choroidal boundaries by using built-in automated retinal segmentation software on two separate sessions. Observers were masked to each other's and their own previous readings. A standardized grid centered on the fovea was positioned automatically by OCT software, and values for average CVs and total CVs in three concentric rings were noted. The agreement between the intraobserver measurements or interobserver measurements was assessed using the concordance correlation coefficient (CCC). Bland-Altman plots were used to assess the clinically relevant magnitude of differences between inter-and intraobserver measurements.RESULTS. The interobserver CCC for the overall average CV was very high, 0.9956 (95% confidence interval [CI], 0.991-0.9968). CCCs for all three Early Treatment Diabetic Retinopathy Study concentric rings between two graders was 0.98 to 0.99 (95% CI, 0.97-0.98). Similarly intraobserver repeatability of two graders also ranged from 0.98 to 0.99. The interobserver coefficient of reproducibility was approximately 0.42 (95% CI, 0.34-0.5 mm(3)) for the average CV.CONCLUSIONS. CV measurement by manual segmentation using built-in automated retinal segmentation software on EDI-SD-OCT is highly reproducible and repeatable and has a very small range of variability. (Invest Ophthalmol Vis Sci. 2012; 53: 2274-2280) DOI:10.1167/iovs.12-9435