Intraorgan Targeting of Gold Conjugates for Precise Liver Cancer Treatment
Intraorgan Targeting of Gold Conjugates for Precise Liver Cancer Treatment
复制标题
金缀合物的器官内靶向用于精准肝癌治疗
DOI：
10.1021/acsami.7b08969
复制
发表时间：
2017-09-20
影响因子：
9.5
通讯作者：
Ding, Ya
中科院分区：
文献类型：
--
作者：
Gao, Yuan-Yue;Chen, Huan;Ding, Ya
Intraorgan targeting of chemical drugs at tumor tissues is essential in the treatment of solid tumors that express the same target receptor as normal tissues. Here, asialoglycoprotein receptor (ASGP-R)-targeting paclitaxel-conjugated gold nanoparticles (Gal/ PTX-GNPs) are fabricated as a demonstration to realize the precise treatment of liver cancer. The enhanced biological specificity and therapeutic performance of drugs loaded on nanoparticles not only rely on the ligands on carriers for receptor recognition but are also determined by the performance of gold conjugates with designed structure. The tumor cell selectivity of the designed conjugates in liver tumor (HepG2) cells is close to six times of that incubated with control conjugates without galactose modification in liver normal (L02) cells. The drug level in tumor versus liver of Gal/PTX-GNPs is 121.0% at 8 h post injection, a 15.7 fold increase in the tumor specificity compared to that of GNPs conjugated with PTX only. This intraorgan-targeting strategy results in a considerable improvement of performance in treating both Heps heterotopic and orthotopic xenograft tumor models, which is expected to be used for the enhanced antitumor efficacy and reduced hepatotoxicity in liver cancer treatment.
