Masters athletes exhibit larger regional brain volume and better cognitive performance than sedentary older adults.
Masters athletes exhibit larger regional brain volume and better cognitive performance than sedentary older adults.
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DOI：
10.1002/jmri.24085
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发表时间：
2013-11-01
期刊：
影响因子：
--
通讯作者：
Zhang, Rong
中科院分区：
文献类型：
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作者：
Tseng, Benjamin Y;Uh, Jinsoo;Zhang, Rong
目得：研究大师赛运动员和久坐不动的老年人之间与年龄相关的脑组织浓度下降的差异。材料和方法：12名大师运动员（MA）（3名女性，年龄= 72.4 ± 5.6岁，耐力训练>15年），12名年龄和教育水平相似的久坐老年人（SE）（4名女性，年龄= 74.6 ± 4.3岁）和9名年轻对照（YC）（4名女性，年龄= 27.2 ± 3.6岁）参与。T1加权高分辨率（1 × 1 × 1mm（3））图像。进行基于体素的分析以通过t检验鉴定显示组织浓度差异的簇。认知功能进行了评估，使用标准的临床电池集中在执行功能和memory.Results：两个MA和两个SE无法完成磁共振成像（MRI）的研究。SE和MA均显示，在上级、下级和中间额回、上级颞回、中央后回和扣带回中，灰质（GM）浓度低于YC（PFDR校正< 0.001），在额下回和中央前回中，白色物质（WM）浓度低于YC（PFDR校正< 0.005）。值得注意的是，MA在与视觉空间功能、运动控制和工作记忆相关的脑回下、楔叶和楔前叶区域中显示出比SE更高的GM和WM浓度（PFDR校正< 0.005）。在控制估计的智力，MA优于SE的任务的字母（P < 0.01）和类别（P < 0.05）fluency.CONCLUSION：终身运动可能会带来好处的某些方面的执行功能和年龄相关的脑组织损失的区域相关的视觉空间功能，运动控制和工作记忆中的老年人。
PURPOSE: To investigate differences in the age-related decline in brain tissue concentration between Masters athletes and sedentary older adults.MATERIALS AND METHODS: Twelve Masters athletes (MA) (three females, age = 72.4 ± 5.6 years, endurance training >15 years), 12 sedentary elderly (SE) similar in age and educational level (four females, age = 74.6 ± 4.3 years), and nine young controls (YC) (four females, age = 27.2 ± 3.6 years) participated. T1-weighted high-resolution (1 * 1 * 1mm(3) ) images were acquired. Voxel-based analysis was conducted to identify clusters showing tissue concentration differences with t-tests. Cognitive function was assessed using a standard clinical battery focused on executive function and memory.RESULTS: Two MA and two SE were unable to complete the magnetic resonance imaging (MRI) study. Both SE and MA showed lower gray matter (GM) concentrations than YC in the superior, inferior and middle frontal gyrus, superior temporal gyrus, postcentral gyrus, and the cingulate gyrus (PFDR-corrected < 0.001) and lower white matter (WM) concentrations in the inferior frontal gyrus and precentral gyrus (PFDR-corrected < 0.005). Notably, MA showed higher GM and WM concentrations than SE in the subgyral, cuneus, and precuneus regions related to visuospatial function, motor control, and working memory (PFDR-corrected < 0.005). After controlling for estimated intelligence, MA outperformed SE on tasks of letter (P < 0.01) and category (P < 0.05) fluency.CONCLUSION: Life-long exercise may confer benefits to some aspects of executive function and age-related brain tissue loss in the regions related to visuospatial function, motor control, and working memory in older adults.