Non-confirmation of thalidomide induced teratogenesis in rats and mice.
Non-confirmation of thalidomide induced teratogenesis in rats and mice.
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未证实沙利度胺可诱导大鼠和小鼠致畸。
DOI：
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
James G. Wilson
中科院分区：
文献类型：
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作者：
W. Scott;R. Fradkin;James G. Wilson
据报道，溶解在吐温20和生理盐水的1：3混合物中的沙利度胺，经腹膜内给予妊娠小鼠和大鼠，可诱导多种畸形，包括四肢畸形，这是灵长类综合征的特征。本文报告的研究试图证实这些发现，但没有成功，尽管所用的啮齿动物品系不同。在两个物种的胎儿中观察到低水平的非特异性畸形，据报告，在小鼠和大鼠中分别导致47%和92%的畸形率。差异的一个可能来源是吐温20，在这些研究中，吐温20在早期研究中报告为无毒的剂量水平下具有致死性毒性。
It has been reported that thalidomide, dissolved in a 1:3 mixture of Tween 20 and physiological saline and administered intraperitoneally to pregnant mice and rats induces a variety of malformations, including limb deformaties, characteristic of the primate syndrome. The studies reported herein attempted to confirm these findings without success although the rodent strains used were not the same. A low level of non-specific malformations was observed in the fetuses of both species at dose levels reported to cause a 47 percent and 92 percent rate of malformation in mice and rats respectively. One possible source of difference was Tween 20 which was toxic to the point of lethality in these studies at dose levels reported to be non-toxic in the earlier studies.