Twenty-Three Years of Hypocretins: The "Rosetta Stone" of Sleep/Arousal Circuits
Twenty-Three Years of Hypocretins: The "Rosetta Stone" of Sleep/Arousal Circuits
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DOI：
10.1159/000514961
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发表时间：
2021-01-01
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影响因子：
--
通讯作者：
de Lecea, Luis
中科院分区：
文献类型：
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作者：
de Lecea, Luis
在过去的二十年里，下丘脑肌酸/食欲素(HCRT)的发现使睡眠科学发生了革命性的变化。解剖示踪方法、光遗传学和药理学的结合勾勒出了HCRT系统的功能输入和输出的蓝图。在这里，我们讨论了几种HCRT作用的模型，这些模型涉及生理变量、昼夜输出量和睡眠稳态之间的整合。在细胞水平上生成睡眠-觉醒周期的活动图将使研究人员能够破译模拟HCRT网络操作的计算框架。(C)2021年作者(S)由S.Karger AG，巴塞尔出版
The discovery of the hypocretins/orexins (HCRTs) has revolutionized sleep science in the last two decades. A combination of anatomical tracing methods, optogenetics, and pharmacology is delineating a blueprint of functional inputs and outputs of the HCRT system. Here, we discuss several models of HCRT action that involve the integration between physiological variables, circadian output, and sleep homeostasis. Generation of activity maps during the sleep-wake cycle at the cellular level will allow investigators to decipher computational frameworks modeling operations of HCRT networks. (c) 2021 The Author(s) Published by S. Karger AG, Basel