HLA DISEASE ASSOCIATION AND PROTECTION IN HIV-INFECTION AMONG AFRICAN-AMERICANS AND CAUCASIANS
HLA DISEASE ASSOCIATION AND PROTECTION IN HIV-INFECTION AMONG AFRICAN-AMERICANS AND CAUCASIANS
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DOI：
10.1159/000163671
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发表时间：
1991-09-01
期刊：
影响因子：
5
通讯作者：
BRACKIN, B
中科院分区：
文献类型：
--
作者：
CRUSE, JM;BRACKIN, MN;BRACKIN, B
在先前的研究中，我们发现与高加索人群相比，非洲裔美国人群体中显性艾滋病的进展更快，这反映在早期研究中在非裔美国人群体中检测到的CD4+淋巴细胞的绝对数明显较低。目前的研究阐明了一些可能的遗传因素，这些因素可能有助于疾病关联或预防艾滋病毒感染。用改良的Amos分型法检测A、B、C、DR和DQw抗原的表型。用NIH评分表示摄取台盼蓝的阳性细胞。用相当于X-2近似的比例检验来比较疾病人群(n=62；38名非洲裔美国人，24名高加索人)和种族匹配的正常异性当地对照组(323名非洲裔美国人，412名高加索人)。显著的p值根据所检测的人类白细胞抗原的数量进行了校正。与非裔美国人可能免受感染相关的HL A标志物是CW4和DRw6，而高加索人则没有表达。在非裔美国人中存在A31、B35、Cw6、Cw7、DR5、DR6、DR11、Drw12、DQw6和DQw7等疾病关联标记，而在高加索人群中存在A28、Aw66、Bw48、Bw65、Bw70、Cw7、Cw8、Dru10、Drw12、DQw6和DQw7。在这项研究中，疾病关联标志物的最高表型频率是没有卡波西肉瘤的艾滋病毒感染的非裔美国人群体中的HLADR5(62.9%)，而地区对照组的表型频率为28.9%(p=0.0012)。我们的结论是，遗传因素在艾滋病毒感染中确实起到了作用，因为接触艾滋病病毒的人中只有50%-60%会被感染。
In a previous investigation, we demonstrated an increased progression of overt AIDS in the African American population compared to the Caucasian population as reflected by the significantly lower absolute number of CD4+ lymphocytes detected in the African American population in an earlier study. The present study elucidates some of the possible genetic factors which may contribute to disease association or protection against HIV infection. The HLA phenotypes expressed as A, B, C, DR and DQw antigens were revealed by the Amos-modified typing procedure. NIH scoring was utilized to designate positive cells taking up trypan blue. A test of proportion equivalent to the chi-2 approximation was used to compare the disease population (n = 62; 38 African Americans, 24 Caucasians) to race-matched normal heterosexual local controls (323 African Americans, 412 Caucasians). Significant p values were corrected for the number of HLA antigens tested. HLA markers associated with possible protection from infection for African Americans were Cw4 and DRw6, whereas Caucasians expressed none. Disease association markers present in the African American population were A31, B35, Cw6, Cw7, DR5, DR6, DR11, Drw12, DQw6 and DQw7, whereas in the Caucasian population A28, Aw66, Bw48, Bw65, Bw70, Cw7, Cw8, DRw10, DRw12, DQw6 and DQw7 were demonstrated. The highest phenotypic frequency for a disease association marker in the study was for HLA-DR5 (62.9%) in the HIV-infected African American population without Kaposi's sarcoma compared to a frequency of 28.9% for the regional control group (p = 0.0012). We conclude that genetic factors do have a role in HIV infection since only 50-60% of those exposed to the AIDS virus will become infected.