Sclerosing Pneumocytoma of the Lung: A Case Report
Sclerosing Pneumocytoma of the Lung: A Case Report
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DOI：
10.7860/jcdr/2017/22279.9271
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发表时间：
2017-02-01
影响因子：
0.2
通讯作者：
Sunderaj, Ramya Rathinam
中科院分区：
文献类型：
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作者：
Arumugam, Vasugi Gramani;Joseph, Leena Dennis;Sunderaj, Ramya Rathinam
肺硬化性肺细胞瘤(PSP)是一种罕见的肺部肿瘤，通常为良性。诊断是在其他临床情况下进行胸部X光或胸部CT扫描后偶然做出的。我们报告一位七岁女孩因评估前纵隔肿块而入院的PSP病例。临床上，认为是畸胎瘤或其他生殖细胞瘤的肿块被切除并送去做组织病理学检查。大体上，我们接受了一个13x11x8厘米的全肺切除标本，在肺下叶和中叶内侧有一个结节状坚硬的灰色白色病变，直径为7.5x5.5x5厘米。肉眼可见胸膜受累并粘连于肺。镜下可见肺内边界不清的病变，有广泛的纤维化和淋巴浆细胞渗入。病变由圆形至卵圆形细胞组成，细胞边界不清，胞浆中等嗜酸性，胞核淡淡。进行免疫组织化学(IHC)标记，皮损细胞上皮膜抗原(EMA)和甲状腺转录因子-1(TTF-1)呈阳性。手术切除后预后良好，患者情况良好。
Pulmonary Sclerosing Pneumocytoma (PSP) is a rare tumour of the lung and is always benign. Diagnosis is made incidentally following chest X-ray or chest CT scan performed for other clinical conditions. We report a case of PSP in a seven-year-old girl who got admitted for evaluation of an anterior mediastinal mass. Clinically, thought of teratoma or other germ cell tumour the mass was excised and sent for histopathological examination. Grossly, we received a pneumonectomy specimen measuring 13x11x8 cm with a nodular firm grey white lesion in the medial aspect of lower and middle lobe measuring 7.5x5.5x5 cm. Macroscopically, pleura was involved and adherent to the lung. Microscopy showed, an ill-defined lesion in the lung with extensive fibrosis and lymphoplasmacytic infiltrate. The lesion was composed of round to oval cells with ill defined cell border, moderate eosinophilic cytoplasm and bland nuclei. A panel of Immunohistochemical (IHC) markers was performed and the lesional cells were positive for Epithelial Membrane Antigen (EMA) and Thyroid Transcription Factor-1 (TTF-1). The prognosis after surgical resection is good and the patient is doing well.