Autoimmune Pancreatitis Associated with Various Extrapancreatic Lesions during a Long-term Clinical Course Successfully Treated with Azathioprine and Corticosteroid Maintenance Therapy
Autoimmune Pancreatitis Associated with Various Extrapancreatic Lesions during a Long-term Clinical Course Successfully Treated with Azathioprine and Corticosteroid Maintenance Therapy
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DOI：
10.2169/internalmedicine.48.2695
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Joh, Takashi
中科院分区：
文献类型：
--
作者：
Naitoh, Itaru;Nakazawa, Takahiro;Joh, Takashi
自身免疫性胰腺炎（AIP）常与系统性胰腺外病变相关，igg4相关自身免疫性疾病的概念已被提出。我们报告一位62岁的女性AIP在长期的临床过程中伴有各种胰腺外病变。这些胰腺外病变发生在停止类固醇治疗后。AIP前发生硬化性涎腺炎，AIP后发生自身免疫性感音神经性耳聋、过敏性紫癜和毛细血管内增生性肾小球肾炎。然而，在泼尼松龙和硫唑嘌呤维持治疗开始后的5年内没有观察到复发。
Autoimmune pancreatitis (AIP) is often associated with systemic extrapancreatic lesions, and the concept of IgG4-related autoimmune disease has been proposed. We report a 62-year-old woman with AIP associated with various extrapancreatic lesions during a long-term clinical course. These extrapancreatic lesions occurred after the withdrawal of steroid therapy. Sclerosing sialadenitis occurred before AIP, whereas autoimmune sensorineural hearing loss, allergic purpura and endocapillary proliferative glomerulonephritis occurred after AIP. However, no relapse was observed for 5 years after the start of maintenance therapy with prednisolone and azathioprine.