Catunaregin and Epicatunaregin, Two Norneolignans Possessing an Unprecedented Skeleton from Catunaregam spinosa
Catunaregin and Epicatunaregin, Two Norneolignans Possessing an Unprecedented Skeleton from Catunaregam spinosa
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DOI：
10.1002/hlca.200900193
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发表时间：
2010-01-01
影响因子：
1.8
通讯作者：
Zhang, Si
中科院分区：
文献类型：
--
作者：
Gao, Guang-Chun;Luo, Xiong-Ming;Zhang, Si
从刺茶树皮中分离得到2个新的具有O-桥基呋喃并呋喃环的去甲木脂素(Catunaregin，1)和表木脂素(epicatunaregin，2)，以及3个已知的新木脂素，它们分别是：虚构的，Balanophonin，和5‘’-甲氧基-4‘’-O-(8-愈创木基甘油)布地兰醇A。一位中国红树林合伙人。通过波谱手段，包括二维核磁共振技术，确定了它们的结构。化合物1和2对乳腺癌F10细胞有一定的抑制作用。
Catunaregin (1) and epicatunaregin (2), two novel norneolignans with a unique O-bridged furopyran ring, together with three known neolignans, ficusal, balanophonin, and 5 ''-methoxy-4 ''-O-(8-guaiacylglycerol)buddlenol A, were isolated from the stem bark of Catunaregam spinosa. a Chinese mangrove associate. Their structures were elucidated by spectroscopic means, including two-dimensional NMR techniques. Compounds 1 and 2 exhibited moderate inhibition against the mammary cancer F10 cell line.