Cerebral transmitter precursors and metabolites in advanced renal disease.
Cerebral transmitter precursors and metabolites in advanced renal disease.
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晚期肾病中的脑递质前体和代谢物。
DOI：
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发表时间：
1978
影响因子：
11
通讯作者：
G. Curzon
中科院分区：
文献类型：
--
作者：
P. Sullivan;D. Murnaghan;N. Callaghan;B. D. Kantamaneni;G. Curzon
慢性肾脏疾病患者血浆总色氨酸较低，但处于游离状态的比例异常高。脑病患者血浆游离色氨酸、脑脊液色氨酸和脑脊液5-羟基吲哚乙酸升高。脑脊液色氨酸与血浆游离色氨酸的相关性优于与血浆总色氨酸的相关性。血浆和脑脊液酪氨酸浓度正常，但脑脊液同型香草酸升高，尤其是脑病患者。讨论了这些变化在晚期肾脏疾病中的可能意义。
Patients with chronic renal disease had low plasma total tryptophan but an abnormally high proportion of this was in the free state. The subjects with encephalopathy had raised plasma free tryptophan, CSF tryptophan, and CSF 5-hydroxyindoleacetic acid. CSF tryptophan correlated better with plasma free than with plasma total tryptophan. Plasma and CSF tyrosine concentrations were normal but CSF homovanillic acid was raised especially in subjects with encephalopathy. The possible significance of these changes in advanced renal disease is discussed.