Macular retinal capillary hemodynamics in diabetic patients.
Macular retinal capillary hemodynamics in diabetic patients.
复制标题
糖尿病患者黄斑视网膜毛细血管血流动力学。
DOI：
10.1016/s0161-6420(91)32084-0
复制
发表时间：
1991
期刊：
影响因子：
13.7
通讯作者：
Sinclair,SH
中科院分区：
文献类型：
--
作者：
Sinclair,SH
使用蓝场内视模拟技术对 39 名非高血压胰岛素依赖型糖尿病患者和 24 名年龄匹配的对照受试者进行黄斑视网膜毛细血管血流动力学评估。在糖尿病眼中观察到黄斑毛细血管流速显着增加 25%，同时内视感知白细胞密度下降 37%。当根据 Klein 等人的修改后的综合量表对糖尿病患者的眼睛进行分级时，在无视网膜病变组、轻度背景视网膜病变组和增殖前期或增殖性视网膜病变组中，毛细血管流速升高。与没有视网膜病变的患者相比，患有视网膜病变的患者的内视感知白细胞密度降低更严重，但与综合分级量表的相关性较差。这些结果与以下概念一致：在糖尿病中，毛细血管阻塞（无论是短暂的还是永久性的）可能集中发生在视网膜内，并且由于相对组织缺氧而与邻近微脉管系统中的血管舒张相关。
Macular retinal capillary hemodynamics was evaluated in 39 nonhypertensive insulin-dependent diabetic patients and 24 age-matched control subjects using the blue field entoptic simulation technique. A statistically significant 25% increase in macular capillary flow velocity was observed among the diabetic eyes along with a 37% decrease in the density of the entoptically perceived leukocytes. When the eyes of diabetic patients were graded according to the modified composite scale of Klein et al, capillary flow velocity was elevated in the group without retinopathy as well as in those with mild background retinopathy and those with preproliferative or proliferative retinopathy. The density of the entoptically perceived leukocytes was more severely reduced in those with retinopathy than in those without retinopathy but was poorly correlated with the composite grading scale. These results are consistent with the concept that in diabetes, capillary obstruction, either transient or permanent, may focally occur within the retina associated with vasodilation in the adjacent microvasculature because of relative tissue hypoxia.