Cn3D: sequence and structure views for Entrez
Cn3D: sequence and structure views for Entrez
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DOI：
10.1016/s0968-0004(00)01561-9
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发表时间：
2000-06-01
影响因子：
13.8
通讯作者：
Bryant, SH
中科院分区：
文献类型：
--
作者：
Wang, YL;Geer, LY;Bryant, SH
图1小鼠Zif 268锌指DNA复合物（PDB代码1AAY，链A）的结构和与人Wilms肿瘤抑制蛋白的突变形式的BLAST比对（GenBank登录号AAB 20112）。1）、执行带序列导入功能。与Denys-Drash综合征相关的突变位点D396 N在序列和结构窗口中突出显示（黄色）。从3D结构的角度来看，很明显，小鼠蛋白质中的相应残基参与蛋白质-DNA相互作用。
Figure 1 Structure of mouse Zif268 zinc-finger DNA complex (PDB code 1AAY, chain A) and a BLAST alignment with a mutant form of human Wilms’ tumor suppressor protein (GenBank accession no. AAB20112. 1), carried out with the sequence import function. The site of mutation D396N, associated with Denys–Drash syndrome, has been highlighted (in yellow) in the sequence and structure windows. From the 3D structure view it is clear that the corresponding residue in the mouse protein is involved in protein–DNA interaction.