Morphometry-based measurements of the structural response to whole-brain radiation.
Morphometry-based measurements of the structural response to whole-brain radiation.
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DOI：
10.1007/s11548-014-1128-3
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发表时间：
2015-04
影响因子：
3
通讯作者：
Guerrero T
中科院分区：
文献类型：
--
作者：
Fuentes D;Contreras J;Yu J;He R;Castillo E;Castillo R;Guerrero T
应用形态测量技术对接受全脑放射治疗的颅内恶性肿瘤患者的正常组织治疗反应进行量化。回顾性分析了N = 15例患者的辐照前和辐照后磁共振成像（MRI）数据集。在大脑和脑室中定量测量相对于照射前的体积变化。测量值与照射的时间间隔相关。入选标准包括颅脊髓放疗、放疗前MRI、至少一次随访MRI和无疾病进展。对每个图像上的大脑进行分割以去除颅骨，并将其配准到初始治疗前扫描。使用变形雅可比矩阵的形态计量学分析和基于直接模板配准的脑结构分割来测量平均体积变化。变形形态测量法和直接分割法测得的平均脑体积萎缩分别为-0.2%和-3%。变形形态测量法和直接分割法测得的平均心室体积扩张分别为21%和20%。本研究开发了一种图像处理管道，用于对放射治疗引起的脑组织体积变化进行形态学监测。结果表明，定量形态学监测是可行的，并可能提供额外的信息，在评估反应。
Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies. Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures. An average cerebral volume atrophy of −0.2 and −3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively. The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.