Magnetoencephalography in partial epilepsy: Clinical yield and localization accuracy
Magnetoencephalography in partial epilepsy: Clinical yield and localization accuracy
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DOI：
10.1002/ana.410420413
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发表时间：
1997-10-01
影响因子：
11.2
通讯作者：
Rowley, HA
中科院分区：
文献类型：
--
作者：
Knowlton, RC;Laxer, KD;Rowley, HA
本研究的目的是确定（1）根据癫痫类型的脑磁图（MEG）的产量，（2）MEG棘波源是否与局灶性癫痫病理学共定位，以及（3）当头皮发作脑电图（EEG）或磁共振成像（MRI）无法定位时，MEG是否可以识别致痫区。研究了10例患者的癫痫发作、3例患者的新皮质颞叶癫痫发作和9例患者的颞外叶癫痫发作。采用37通道生物磁仪同时记录脑磁图和脑电图。在典型的2-3小时MEG记录期间，在22名患者中的16名中观察到发作间期癫痫样活动。新皮质癫痫患者的MEG定位率（92%）高于内侧颞叶癫痫患者（50%）。在6例局灶性致痫性病变患者中，5例MEG棘波源与病灶共定位。在12例非定位（模糊异常或正常）MRI患者中，11例MEG棘波源定位于致痫区区域，最终由所有临床和EEG信息（包括颅内EEG）定义。总之，MEG可以可靠地定位颞叶和颞外叶癫痫患者的棘波放电源。MEG有时提供MRI或常规头皮发作EEG无法提供的非侵入性定位数据。
The goals of this study were to determine (1) the yield of magnetoencephalography (MEG) according to epilepsy type, (2) if MEG spike sources colocalize with focal epileptogenic pathology, and (3) if MEG can identify the epileptogenic zone when scalp ictal electroencephalogam (EEG) or magnetic resonance imaging (MRI) fail to localize it. Twenty-two patients with mesial temporal (10 patients), neocortical temporal (3 patients), and extratemporal lobe epilepsy (9 patients) were studied. A 37-channel biomagnetometer was used for simultaneously recording MEG with EEG. During the typical 2-3-hour MEG recording session, interictal epileptiform activity was observed in 16 of 22 patients. MEG localization yield was greater in patients with neocortical epilepsy (92%) than in those with mesial temporal lobe epilepsy (50%). In 5 of 6 patients with focal epileptogenic pathology, MEG spike sources were colocalized with the lesions. In 11 of 12 patients with nonlocalizing (ambiguous abnormalities or normal) MRI, MEG spike sources were localized in the region of the epileptogenic zone as ultimately defined by all clinical and EEG information (including intracranial EEG). In conclusion, MEG can reliably localize sources of spike discharges in patients with temporal and extratemporal lobe epilepsy. MEG sometimes provides noninvasive localization data that are not otherwise available with MRI or conventional scalp ictal EEG.