CHOLINERGIC RECEPTOR-BINDING AND AUTORADIOGRAPHY IN BRAINS OF NON-NEUROLOGICAL AND SENILE DEMENTIA OF ALZHEIMER-TYPE PATIENTS
CHOLINERGIC RECEPTOR-BINDING AND AUTORADIOGRAPHY IN BRAINS OF NON-NEUROLOGICAL AND SENILE DEMENTIA OF ALZHEIMER-TYPE PATIENTS
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DOI：
10.1016/0006-8993(83)90879-x
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发表时间：
1983-01-01
期刊：
影响因子：
2.9
通讯作者：
HENKE, H
中科院分区：
文献类型：
--
作者：
LANG, W;HENKE, H
Muscarinic and nicotinic cholinergic receptor distribution was studied by dry-mount autoradiography in brains obtained postmortem from patients with senile dementia of Alzheimer-type (SDAT) and non-neurological controls. Sections were incubated with either [N-methyl-3H]scopolamine, ([3H]NMS) or [125I].alpha.-bungarotoxin, ([125I].alpha.-BTX). No significant difference in the affinity and number of muscarinic and nicotinic receptors was found in hippocampus, frontal, temporal and cingulate cortex between SDAT patients and non-neurological controls. Some SDAT cases showed diffuse instead of laminar [3H]NMS labeling in cortical regions. The labeling pattern was not affected by the presence of neuritic plaques and neurofibrillary tangles.
