EFFECT OF PROLONGED GALACTOSE CONSUMPTION ON GALACTOSE TOLERANCE IN YOUNG HEALTHY HUMANS
EFFECT OF PROLONGED GALACTOSE CONSUMPTION ON GALACTOSE TOLERANCE IN YOUNG HEALTHY HUMANS
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DOI：
10.1159/000177563
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发表时间：
1990-01-01
影响因子：
3.9
通讯作者：
ALLOUSSI, S
中科院分区：
文献类型：
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作者：
BIRLOUEZARAGON, I;ALLOUSSI, S
这项研究是在两组健康的年轻受试者中进行的。一组（n = 8）给予单次口服剂量的半乳糖（0.5 g/kg体重），并在40 min后进行单次血半乳糖测量。第二组（n = 16）每天补充0.5 g/kg半乳糖，持续15天，并测量血液半乳糖和半乳糖醇。在测试期的第一天，一些受试者似乎比其他受试者耐受半乳糖的能力差：半乳糖醇出现在他们的血浆中，并且可能与血浆中没有检测到半乳糖醇的受试者相比显著更高的半乳糖血症有关。然而，在摄入半乳糖15天后，半乳糖耐受性较低的受试者似乎已经适应，如血液半乳糖的显著降低和半乳糖醇的消失所示。在半乳糖耐受的受试者中没有发现变化。男性和女性之间无显著差异。
This study was carried out on two groups of healthy young subjects. One group (n = 8) was given as single oral dose of galactose (0.5 g/kg body weight), and a single measurement of blood galactose was made 40 min later. A second group (n = 16) was given a daily supplement of 0.5 g/kg galactose for 15 days, and blood galactose and galactitol were measured. On the first day of the test period, some subjects seemed to tolerance galactose less well than others: galactitol appeared in their plasmas and could be related to a significantly higher galactosaemia than that of subjects without detectable galactitol in the plasma. However, after 15 days of galactose intake, the less galactose-tolerant subjects appeared to have adapted, as indicated by the significant decrease in the blood galactose and the disappearance of galactitol. No change was found in the galactose-tolerant subjects. No significant difference was found between males and females.