Magneto-ultrasonic heating with nanoparticles
Magneto-ultrasonic heating with nanoparticles
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DOI：
10.1016/j.jmmm.2018.11.062
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发表时间：
2019-03-15
影响因子：
2.7
通讯作者：
Jozefczak, A.
中科院分区：
文献类型：
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作者：
Kaczmarek, K.;Hornowski, T.;Jozefczak, A.
近年来，多模式热疗的应用引起了人们极大的兴趣。热疗是一种将组织温度控制在42-45摄氏度的方法，是一种非常有前途的抗癌药物。超声波、交变磁场、无线电波、激光等都可以引起热疗。在我们的研究中，我们将联合收割机磁热疗与超声热治疗相结合，以促进更有效、创新的声磁治疗。实验是使用掺杂有磁性纳米颗粒的超声幻影进行的。这些纳米颗粒的作用类似于声敏剂，并成为补充超声衰减的来源，从而导致温度升高。由于它们对磁场的敏感性，它们也是磁热疗的热源。为了研究多模式热疗的热效应，同时用聚焦超声束照射体模并暴露于交流磁场。我们证明，这种双重的热刺激的phantomerase掺杂纳米粒子提供了更好的加热效率，使加热过程中更精确的控制。磁超声加热产生更有效的热疗，并且在较低磁性颗粒浓度下治疗癌症方面具有很大的应用潜力。磁热疗和超声热疗的耦合为发展新的、创新的声磁热疗提供了可能。
Recently, there has been a great interest in the application of multimodal hyperthermia. Hyperthermia, a controlled increase of temperature in tissues up to 42-45 degrees C, is a very promising anti-cancer medical treatment. Hyperthermia can be induced by means of ultrasound wave, alternating magnetic field, radiowave, laser light, etc. In our research, we combine magnetic hyperthermia with ultrasound thermal treatment to facilitate a more efficient, innovative sonomagnetic therapy. The experiments are performed using ultrasound phantoms doped with magnetic nanoparticles. These nanoparticles act like sonosensitizers and become the source of supplementary ultrasound attenuation which consequently leads to the increase of temperature. Because of their sensitivity to magnetic field they are also the source of heat in magnetic hyperthermia. In order to investigate the thermal effect of multimodal hyperthermia, phantoms are simultaneously irradiated with a focused ultrasound beam and exposed to the AC magnetic field. We demonstrate that this double thermal stimulation of phantoms doped with nanoparticles provides better heating efficiency which enables more precise control over the heating process. Magneto-ultrasonic heating creates more effective hyperthermia and has a big application potential in treating cancer at a lower magnetic particle concentration. The coupling of magnetic and ultrasonic hyperthermia gives the possibility for developing the new, innovative sonomagnetic thermal therapy.