Rag proteins regulate amino-acid-induced mTORC1 signalling.
Rag proteins regulate amino-acid-induced mTORC1 signalling.
复制标题
DOI：
10.1042/bst0370289
复制
发表时间：
2009-02
影响因子：
3.9
通讯作者：
Sabatini DM
中科院分区：
文献类型：
--
作者：
Sancak Y;Sabatini DM
血清和营养敏感蛋白激酶mTOR是细胞生长和存活的主要调节因子。营养素调节mTOR的机制一直是mTOR领域的主要未回答的问题之一。鉴定作为mTOR的氨基酸信号传导介导剂的GTP酶的rag家族是理解该机制的重要一步。
The serum and nutrient-sensitive protein kinase mTOR is a master regulator of cell growth and survival. The mechanisms through which nutrients regulate mTOR have been one of the major unanswered questions in the mTOR field. Identification of rag family of GTPases as mediators of amino acid signaling to mTOR is an important step towards understanding this mechanism.