Functional magnetic resonance imaging before and after aphasia therapy - Shifts in hemodynamic time to peak during an overt language task
Functional magnetic resonance imaging before and after aphasia therapy - Shifts in hemodynamic time to peak during an overt language task
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DOI：
10.1161/01.str.0000110983.50753.9d
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发表时间：
2004-02-01
期刊：
影响因子：
8.3
通讯作者：
Briggs, RW
中科院分区：
文献类型：
--
作者：
Peck, KK;Moore, AB;Briggs, RW
背景和目的 - 比较失语症患者治疗前后激活皮质区域血流动力学反应的时间特征，将有助于深入了解任务表现改善与血氧水平依赖性 (BOLD) 功能 MRI (fMRI) 信号变化之间的关系。本研究调查了治疗前后激活的感兴趣区域 (ROI) 血流动力学反应达到峰值的时间 (TTP) 的差异，并将其与任务表现的变化联系起来。方法 - 三名失语症患者和 3 名对照者明显地生成了一个针对某一类别的单一样本。对于患者，比较语言治疗前后选定 ROI 中血流动力学反应的 TTP。将听觉线索和语言反应之间的时间差异与听觉和运动皮层之间的 TTP 差异进行比较。结果 - 在明显的单词生成过程中，失语症患者和对照者中选定的 ROI 均被显着激活。在失语症患者中，康复后从听觉提示到言语反应的时间差异以及听觉和运动皮层之间的 TTP 差异均下降，变得与对照组相似。结论 - 研究结果表明（1）康复提高了找词过程的速度； (2) TTP分析对这种功能变化敏感，可以用来代表行为的改善； (3) 监测可能与血流动力学反应的时间模式相关的行为表现很重要。
Background and Purpose - Comparing the temporal characteristics of hemodynamic responses in activated cortical regions of aphasic patients before and after therapy would provide insight into the relationship between improved task performance and changes in blood oxygenation level - dependent ( BOLD) functional MRI ( fMRI) signal. This study investigated differences in the time to peak (TTP) of hemodynamic responses in activated regions of interest (ROIs), before and after therapy, and related them to changes in task performance.Methods - Three aphasic patients and 3 controls overtly generated a single exemplar in response to a category. For the patients, TTP of hemodynamic responses in selected ROIs was compared before and after language therapy. The timing differences between auditory cues and verbal responses were compared with TTP differences between auditory and motor cortices.Results - The selected ROIs were significantly activated in both aphasic patients and controls during overt word generation. In the aphasic patients, both the timing difference from auditory cues to verbal responses and the TTP difference between auditory and motor cortices decreased after rehabilitation, becoming similar to the values found in controls.Conclusions - Findings indicate that ( 1) rehabilitation increased the speed of word-finding processes; ( 2) TTP analysis was sensitive to this functional change and can be used to represent improvement in behavior; and ( 3) it is important to monitor the behavioral performance that might correlate with the temporal pattern of the hemodynamic response.