The Association of Low-Grade Systemic Inflammation with Hypertensive Retinopathy
The Association of Low-Grade Systemic Inflammation with Hypertensive Retinopathy
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DOI：
10.3109/10641963.2010.496519
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发表时间：
2010-01-01
影响因子：
12.3
通讯作者：
Akar, Yusuf
中科院分区：
文献类型：
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作者：
Coban, Erkan;Nizam, Ilknur;Akar, Yusuf
高敏C反应蛋白（hs-CRP）是系统性低度炎症的标志物。高血压性视网膜病变（HR）的病理生理机制尚未完全确定。血压升高（BP）本身并不能完全解释视网膜病变的程度，可能涉及其他致病机制，如低度炎症。因此，本研究旨在回答以下问题。(i)hs-CRP水平在HR中会发生变化吗？(ii)HR程度与hs-CRP水平是否存在相关性？本研究纳入84例高血压伴HR患者，根据Keith-Wagener分级将高血压患者分为两组。第1组为Ⅰ级HR患者42例，第2组为Ⅱ级HR患者42例，选择年龄、性别、体重指数（BMI）相匹配的健康体检者42例作为对照组。第2组hs-CRP水平显著高于第1组（p = 0.018）和对照组（p = 0.001），第1组也高于对照组（p = 0.002）。hs-CRP与HR程度呈正相关（r = 0.29，p = 0.017）。我们的研究表明，HR和hs-CRP水平之间存在相关性，这可能与全身低度炎症有关。
High-sensitivity C-reactive protein (hs-CRP) is a marker of systemic low-grade inflammation. The pathophysiologic mechanism of hypertensive retiopathy (HR) is not fully established. Elevated blood pressure (BP) alone does not fully account for the extent of retinopathy, other pathogenic mechanisms may be involved, such as low-grade inflammation. Therefore, this study was designed to answer the following questions. (i) Do hs-CRP levels change in HR? (ii) Is there any relation between degree of HR and hs-CRP levels? This study included 84 hypertensive patients with HR. The hypertensive patients were divided into two groups according to the Keith-Wagener classification. Group 1 comprised 42 patients with grade I HR, and Group 2 comprised 42 patients with grade II HR. We selected 42 healthy subjects matched for age, sex, and body mass index (BMI) for control group. The level of hs-CRP in group 2 was significantly higher than in group 1 group (p = 0.018) and control group (p = 0.001), it was also higher in group 1 than in control group (p = 0.002). Also, hs-CRP showed positive correlations with degree of HR (r = 0.29, p = 0.017). Our study suggests that there is a relationship between HR and hs-CRP levels, which may be associated with systemic low-grade inflammation.