Signal transduction: Rhomantic interludes raise blood pressure
Signal transduction: Rhomantic interludes raise blood pressure
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信号转导：浪漫插曲会升高血压
作者：
Andrew P. Somlyo
钙在平滑肌和横纹肌的收缩中起着至关重要的作用。平滑肌调节许多不同血管的管腔大小，包括动脉、气道和肠道，因此它们的异常收缩可能导致哮喘或高血压等疾病。一种名为 Y-27632 的新药可以特异性抑制 Rho 相关激酶，从而降低平滑肌对钙的敏感性。此外，这种药物能够降低动物的高血压。然而，其治疗高血压患者的益处尚未阐明。
Calcium is a crucial player in the contraction of both smooth and striated muscle. Smooth muscles regulate the size of the lumen of many different vessels including the arteries, airways, and gut, and so their abnormal contraction can cause diseases such as asthma or high blood pressure. A new drug called Y-27632, which specifically inhibits the Rho-associated kinases, renders smooth muscles less sensitive to calcium. Furthermore, this drug is able to reduce high blood pressure in animals. However, its benefits in treating patients with high blood pressure have yet to be elucidated.