Prevalence and Risk Factors of Strabismus in a UK Multi-ethnic Birth Cohort
Prevalence and Risk Factors of Strabismus in a UK Multi-ethnic Birth Cohort
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DOI：
10.1080/09273972.2016.1242639
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发表时间：
2016-01-01
期刊：
影响因子：
0.9
通讯作者：
Santorelli, Gillian
中科院分区：
文献类型：
--
作者：
Bruce, Alison;Santorelli, Gillian
目的：为了确定斜视的患病率，类型和早期生活中的危险因素在多种族出生队列的儿童4-5岁的第一年的school.Methods：数据收集前瞻性超过3年的时间（2012-2015年），从儿童参加视力筛查计划提供的矫形师，并进行了在位于布拉德福德市，英国的学校。对17，018名4至5岁儿童的斜视患病率进行了测定。数据链接进行了4563名儿童参加出生在布拉德福德出生队列研究和视力筛查计划。结果：401/17018例（2.4%）儿童有恒定性斜视或间歇性斜视，179/401例（45%）有内斜视，214例（53%）有外斜视，8例（2%）有垂直斜视。在白色英国人、巴基斯坦人和其他种族的儿童中，斜视的总体患病率没有显著差异（P=0.41）。多变量分析显示，英国白色种族的儿童患内斜视的几率是其他种族儿童的两倍（OR 2.4，95% CI：1.1，5.3）。远视平均等效球镜的儿童患内斜视的几率最高（OR 2.0，95% CI：1.7，2.6）。有一些证据表明，种族和平均等效球镜在儿童与内斜视（P=0.058）。结论：斜视的患病率是一致的，与其他人群为基础的研究，在这个队列的儿童4-5岁。白色英国人群中内斜视（持续性或间歇性）的患病率更高，白色英国和巴基斯坦儿童中内斜视的几率随着远视屈光不正的增加而增加。未发现外斜视（持续性或间歇性）与屈光不正、种族或其他早期生活因素有关。
Purpose: To determine the prevalence, types and early-life risk factors associated with strabismus in a multi-ethnic birth cohort of children aged 4-5 years in the first year of school.Methods: Data were collected prospectively over a 3-year period (2012-2015) from children participating in the vision screening program provided by orthoptists and carried out in schools located in the city of Bradford, UK. Prevalence of strabismus was determined for 17,018 children aged 4 to 5 years. Data linkage was undertaken for 4563 children participating in the Born in Bradford birth cohort study and the vision screening program. 4067 children had complete data and were included in the multivariable regression analyses to determine associated factors.Results: 401/17018 (2.4%) children were found to have either a constant or an intermittent strabismus; 179/401 (45%) had an esotropic deviation, 214 (53%) an exotropic deviation, and 8 (2%) had a vertical deviation. No significant difference in the overall prevalence of strabismus was found between the white British, Pakistani, or children of other ethnic origin (P=0.41). Multivariable analysis showed that children of white British ethnicity have twice the odds of having esotropia (OR 2.4, 95% CI: 1.1, 5.3). The odds of having esotropia were highest in children with a hyperopic mean spherical equivalent (OR 2.0, 95% CI: 1.7, 2.6). There was some evidence of an interaction between ethnicity and mean spherical equivalent in children with esotropia (P=0.058).Conclusions: Prevalence of strabismus is consistent with other population-based studies in this cohort of children aged 4-5 years. Prevalence of esotropia (constant or intermittent) is greater in the white British population, odds of esotropia increased with increasing hyperopic refractive error in both white British and Pakistani children. Exotropia (constant or intermittent) was not found to be associated with refractive error, ethnicity, or other early life factors.