NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling.
NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling.
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DOI：
10.1155/2011/195209
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发表时间：
2011
影响因子：
3
通讯作者：
Lindström MS
中科院分区：
文献类型：
--
作者：
Lindström MS
乍一看，核糖体生物发生和染色质重塑是完全不同的过程，但它们有一个共同的问题，即带电核酸和小碱性蛋白之间的相互作用可能导致不必要的细胞内聚集。多功能核酸性伴侣NPM1 （B23/核磷蛋白）在核糖体生物发生、染色质重塑、有丝分裂以及DNA修复、复制和转录的几个阶段都很活跃。此外，NPM1在Myc-ARF-p53通路和SUMO调控中发挥重要作用。然而，NPM1在这些过程中的相对重要性尚不清楚。这里提供的是NPM1各种活动和互动伙伴不断扩大的最新清单。讨论了NPM1在核核和有丝分裂纺锤体中的核输出功能与肿瘤发展的关系。有人认为，NPM1作为组蛋白伴侣的功能可以解释NPM1表达变化后在细胞中观察到的几种作用，但不是全部。未来的挑战是了解NPM1是如何被激活、招募和控制以执行其功能的。
At a first glance, ribosome biogenesis and chromatin remodeling are quite different processes, but they share a common problem involving interactions between charged nucleic acids and small basic proteins that may result in unwanted intracellular aggregations. The multifunctional nuclear acidic chaperone NPM1 (B23/nucleophosmin) is active in several stages of ribosome biogenesis, chromatin remodeling, and mitosis as well as in DNA repair, replication and transcription. In addition, NPM1 plays an important role in the Myc-ARF-p53 pathway as well as in SUMO regulation. However, the relative importance of NPM1 in these processes remains unclear. Provided herein is an update on the expanding list of the diverse activities and interacting partners of NPM1. Mechanisms of NPM1 nuclear export functions of NPM1 in the nucleolus and at the mitotic spindle are discussed in relation to tumor development. It is argued that the suggested function of NPM1 as a histone chaperone could explain several, but not all, of the effects observed in cells following changes in NPM1 expression. A future challenge is to understand how NPM1 is activated, recruited, and controlled to carry out its functions.