Role of elastin-matrix interactions in tumor progression
Role of elastin-matrix interactions in tumor progression
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DOI：
10.1016/s1044-579x(02)00024-x
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发表时间：
2002-06-01
影响因子：
14.5
通讯作者：
Tímár, J
中科院分区：
文献类型：
--
作者：
Lapis, K;Tímár, J
来自文献的数据现在表明，癌细胞可以与独特的细胞外基质蛋白弹性蛋白特异性地相互作用。这种相互作用是由两个层粘连蛋白受体组成的两个弹性蛋白结合蛋白S-半乳糖/弹性连接蛋白(组成弹性蛋白受体/弹性连接蛋白复合体)和半乳糖凝集素-3介导的，研究表明这两种弹性蛋白结合蛋白的表达与多种癌症的侵袭/转移潜能密切相关。这是因为S-GAL/EBP的弹性蛋白结扎可以诱导癌细胞产生运动和有丝分裂信号，并释放各种弹性蛋白酶，这种诱导取决于转移潜能。研究还表明，某些癌细胞可以合成弹性蛋白并表达赖氨酰氧合酶，这为乳腺癌或胃癌等肿瘤中经常出现弹性组织提供了解释。临床病理资料提示弹性肿瘤间质的存在与肿瘤进展有一定的相关性。由于弹性组织可能是血管抑制分子的重要储存库(S)，这种细胞外基质蛋白也可以在肿瘤诱导的血管生成中发挥作用。在实验性肿瘤模型中，可溶性弹性蛋白和弹性蛋白多肽是转移过程的有效抑制物。另一方面，弹性蛋白多肽也可以用来设计靶向治疗，利用这种基质蛋白的独特物理化学性质。综上所述，这些数据表明肿瘤细胞-弹性蛋白相互作用在肿瘤进展中起着重要作用。
Data from the literature now indicate that cancer cells can specifically interact with the unique extracellular matrix protein, elastin. The interaction is mediated by two elastin-bin ding proteins (EBP), S-gal/EBP (organized into the elasin receptor/elastonectin complex) anti galectin-3, components of two laminin receptors, Studies revealed that the expression of both EBPs is closely associated to the invasive/metastatic Potential of various cancer types. This is due to the fact that elastin-ligation of S-gal/EBP induces motogenic, as well as mitogenic signals and releases various elastases from cancer cells and the induction depends on the metastatic potential, Studies also demonstrated that certain cancer cells can synthesize elastin and express lysyl oxydase, providing explanation for frequent appearance of elastic tissue in tumors such as breast or gastric cancers. Clinico-pathological data suggest some correlation with tumor progression of the presence of the elastic tumor stroma. Since elastic tissue may be a significant reservoir of angiostatic molecule(s) this extracellular matrix protein can also have a role in tumor-induced angiogenesis. Soluble elastin as well as elastin peptides are potent inhibitors Of the metastatic process in experimental tumor models. On the other hand, elastin peptides can also be used to design targeted therapies exploiting the unique physicochemical nature of this matrix protein. Altogether, these data suggest a significant role for tumor cell-elastin interactions in tumor progression.