Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia
Asthma is associated with acute chest syndrome and pain in children with sickle cell anemia
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DOI：
10.1182/blood-2006-01-011072
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发表时间：
2006-11-01
期刊：
影响因子：
20.3
通讯作者：
DeBaun, Michael R.
中科院分区：
文献类型：
--
作者：
Boyd, Jessica H.;Macklin, Eric A.;DeBaun, Michael R.
疼痛和急性胸部综合征(ACS)发作是镰状细胞性贫血(SCA)儿童住院的两个最常见的原因。然而，对于这两种情况，几乎没有潜在的可改变的危险因素被确定。在这项前瞻性的婴儿队列研究中，我们检验了哮喘与疼痛和急性冠脉综合征发病率增加有关的假设。一个婴儿队列由291名患有HbSS的非裔美国儿童组成，这些儿童在6个月前参加了针对镰刀细胞病的合作研究，并在5岁以上进行了随访。哮喘的定义是医生诊断、急性哮喘事件或使用哮喘处方药。比较有哮喘和无哮喘儿童的急性冠脉综合征和疼痛发作的发生率。在队列中有17%的人被诊断为哮喘。哮喘与更频繁的急性冠脉综合征发作(0.39比0.20事件/患者年，P<；.001)和疼痛发作(1.39比0.47事件/患者年，P<；.001)相关。总而言之，在患有SCA的儿童中，哮喘与镰状细胞疾病相关的发病率增加有关。发病率，包括急性冠脉综合征和疼痛发作。
Pain and acute chest syndrome (ACS) episodes are 2 of the most common causes of hospitalization in children with sickle cell anemia (SCA). However, very few potentially modifiable risk factors for either condition have been identified. In this prospective infant cohort study, we tested the hypothesis that asthma is associated with an increased incidence rate of pain and ACS episodes. An infant cohort was composed of 291 African American children with hemoglobin SS enrolled in the Cooperative Study for Sickle Cell Disease before age 6 months and followed beyond age 5 years. Asthma was defined by a physician diagnosis, an acute asthma event, or use of prescription asthma medications. The incidence rates of ACS and painful episodes were compared for children with and without asthma. A clinical diagnosis of asthma was made in 17% of the cohort. Asthma was associated with more frequent ACS episodes (0.39 vs 0.20 events per patient year, P < .001) and painful episodes (1.39 vs 0.47 events per patient year, P < .001). In conclusion, in children with SCA, asthma is associated with an increased incidence of sickle cell disease-related. morbidity, including ACS and painful episodes.