Evidence of preference for a high-concentration sucrose solution in alcoholic men
Evidence of preference for a high-concentration sucrose solution in alcoholic men
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DOI：
10.1176/ajp.154.2.269
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发表时间：
1997-02-01
影响因子：
17.7
通讯作者：
Janowsky, D
中科院分区：
文献类型：
--
作者：
KampovPolevoy, A;Garbutt, JC;Janowsky, D
目的：这项研究的目的是在人类中测试动物研究的结果，表明对更浓缩的甜味溶液的偏好与过量饮酒之间的关联。方法：在20个脱毒酒精和37个非酒精的白人男子的享乐反应，以五种不同浓度的蔗糖溶液进行了评价。所有受试者重复品尝0.05，0.10，0.21，0.42和0.83 M蔗糖浓度的溶液，并在两个尺度上测量甜味的强度和溶液的可爱性。结果：在非酒精对照组中，对甜味溶液的反应呈双峰分布，峰值在0.05 M和0.42 M。在酒精组中，65%的受试者喜欢最高的蔗糖浓度（0.83 M），而非酒精组中只有16%。结论：这项探索性研究的结果支持了这一假设，即对更强的甜味溶液的偏好与酒精依赖之间存在正相关。
Objective: The purpose of this study was to test in humans the finding from animal studies indicating an association between preference for more concentrated sweet solutions and excessive alcohol drinking. Method: The hedonic response to five different concentrations of sucrose solution was evaluated in 20 detoxified alcoholic and 37 nonalcoholic Caucasian men. All subjects repetitively tasted solutions with 0.05, 0.10, 0.21, 0.42, and 0.83 M sucrose concentrations and rated themselves on two scales measuring the intensity of sweetness and the likability of the solutions. Results: A bimodal distribution of responses to the sweet solutions occurred in the nonalcoholic comparison group, with peaks at 0.05 M and 0.42 M. In the alcoholic group, 65% of the subjects preferred the highest sucrose concentration (0.83 M), compared with only 16% of the nonalcoholic group. Conclusions: The results of this exploratory study support the hypothesis suggesting a positive association between the preference for stronger sweet solutions and alcohol dependence.