Ventilatory afterdischarge and central respiratory drive interactions in the awake goat.
Ventilatory afterdischarge and central respiratory drive interactions in the awake goat.
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通气后放电和中枢呼吸驱动清醒山羊的相互作用。
DOI：
10.1152/jappl.1994.76.1.416
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Bisgard,GE
中科院分区：
文献类型：
--
作者：
Engwall,MJ;Smith,CA;Dempsey,JA;Bisgard,GE
我们以前已经通过孤立的颈动脉灌注体（CB）技术在清醒山羊中建立了通气后放电（VAD）的存在。在本系列实验中，我们利用该动物准备研究了系统性（中枢神经系统）缺氧、轻度高碳酸血症和低碳酸血症对孤立CB缺氧刺激后通气变量和呼吸肌肌电图活动中VAD表现的影响。在全身等氧正常情况下，CB缺氧终止后30-40 s（时间常数= 16.8 s）的吸气分气量仍高于对照组；然而，对于全身性低碳酸血症，VAD很短（时间常数= 5.5 s），去除CB刺激后通气不足很常见。轻度全身性高碳酸血症时，VAD延长（时间常数为39.9 s）。然而，全身性（中枢神经系统）缺氧没有降低VAD（时间常数为17.0 s）。这些结果表明，VAD的表现对动脉PCO2水平和中枢化学受体活性的敏感性高于对中枢氧合状态的敏感性。在所有条件下，吸气和呼气肌电图活动定性地跟踪了CB刺激和VAD期间的通气情况。
We have previously established the existence of ventilatory afterdischarge (VAD) in the awake goat by means of an isolated perfused carotid body (CB) technique. In the present series of experiments we used this animal preparation to examine the effects of systemic (central nervous system) hypoxia, mild hypercapnia, and hypocapnia on the manifestation of VAD in ventilatory variables and respiratory muscle electromyogram activity after hypoxic stimulation of the isolated CB. With systemic isocapnic normoxia, inspired minute ventilation remains above control for 30–40 s (time constant = 16.8 s) after termination of CB hypoxia; however, with systemic hypocapnia, VAD is short (time constant = 5.5 s) and hypoventilation is common after removal of CB stimulation. During mild systemic hypercapnia, VAD is prolonged (time constant = 39.9 s). However, systemic (central nervous system) hypoxia did not decrease VAD (time constant = 17.0 s). These results indicate that the manifestation of VAD is more sensitive to the level of arterial PCO2 and central chemoreceptor activity than it is to the state of central oxygenation. Inspiratory and expiratory muscle electromyogram activities qualitatively tracked ventilation during CB stimulation and during the VAD period in all conditions.