MOTOR MECHANISMS ASSOCIATED WITH SLOWING OF THE GASTRIC-EMPTYING OF A SOLID MEAL BY AN INTRADUODENAL LIPID INFUSION
MOTOR MECHANISMS ASSOCIATED WITH SLOWING OF THE GASTRIC-EMPTYING OF A SOLID MEAL BY AN INTRADUODENAL LIPID INFUSION
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DOI：
10.1111/j.1440-1746.1989.tb01741.x
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发表时间：
1989-09-01
影响因子：
4.1
通讯作者：
HOUGHTON, LA
中科院分区：
文献类型：
--
作者：
HEDDLE, R;COLLINS, PJ;HOUGHTON, LA
本研究的目的是更好地定义与十二指肠脂质输注减缓胃排空相关的运动现象。10名健康受试者的胃窦、幽门和十二指肠运动被记录在一个压力测量装置中，该装置包括多个灌注侧孔和一个位于幽门两侧的套筒传感器。用放射性核素技术监测标准固体餐的胃排空和近端胃和远端胃之间的食入物分布。当25%的食物排空后，将甘油三酯乳剂注入十二指肠45分钟。灌胃组胃排空速度明显减慢（P< 0.01）。胃排空的减缓与远端胃窦压力波的抑制（P< 0.01）和近端十二指肠压力波的抑制（P< 0.01）、狭窄幽门段压力波的诱导（P< 0.01）以及摄食从远端胃到近端胃的重新分布有关。这些发现表明，幽门分离的压力波、胃内食物分布的变化以及近端十二指肠运动的变化都可能与胃窦运动的变化协同作用，调节胃排空固体。
The aim of this study was to define better the motor phenomena associated with the slowing of gastric emptying by a duodenal lipid infusion. Antral, pyloric and duodenal motility were recorded in 10 healthy subjects with a manometric assembly which incorporated multiple perfused side‐holes and a sleeve sensor positioned astride the pylorus. The gastric emptying of a standard solid meal and the distribution of the ingesta between the proximal and distal stomach were monitored with a radionuclide technique. A triglyceride emulsion was infused into the duodenum for 45 min once 25% of the meal had emptied. The infusion caused significant slowing in the rate of gastric emptying (P< 0.01). This slowing in gastric emptying was associated with the suppression of pressure waves in the distal antrum (P< 0.01) and proximal duodenum (P< 0.01), the induction of pressure waves isolated to a narrow pyloric segment (P< 0.01), and a redistribution of ingesta from the distal to proximal stomach. These findings suggest that pressure waves isolated to the pylorus, changes in the intragastric distribution of ingested food, and changes in proximal duodenal motility may all act in concert with changes in antral motility to regulate the gastric emptying of solids.