Analysis of the centromeric regions of the human genome assembly
Analysis of the centromeric regions of the human genome assembly
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DOI：
10.1016/j.tig.2004.08.008
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发表时间：
2004-11-01
影响因子：
11.4
通讯作者：
Willard, HF
中科院分区：
文献类型：
--
作者：
Rudd, MK;Willard, HF
人类基因组的序列还不完整，每个染色体的着丝粒区域仍然存在主要的缺口，该区域由重复的阿尔法卫星DNA组成。在这篇文章中，我们描述了包括在当前基因组组装中的着丝粒附近的序列，分析了到目前为止已经组装的类似于7Mb的卫星序列，并预测了有待解释的序列的性质。
The sequence of the human genome is not yet complete, and major gaps remain at the centromere region of each chromosome, which is comprised of repetitive alpha satellite DNA. In this article, we describe the sequences in the vicinity of the centromere that are included in the current genome assembly, analyze the similar to7 Mb of satellite that have been assembled thus far and anticipate the nature of the sequences that remain to be accounted for.