CONTRIBUTION OF HYPOTHERMIA TO EFFECTS OF CHLORAL HYDRATE ON FLASH EVOKED-POTENTIALS OF HOODED RATS
CONTRIBUTION OF HYPOTHERMIA TO EFFECTS OF CHLORAL HYDRATE ON FLASH EVOKED-POTENTIALS OF HOODED RATS
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DOI：
10.1016/s0091-3057(84)80045-3
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发表时间：
1984-01-01
影响因子：
3.6
通讯作者：
DYER, RS
中科院分区：
文献类型：
--
作者：
HETZLER, BE;DYER, RS
The contribution of hypothermia to the effects of chloral hydrate on the flash evoked potential (FEP) of hooded rats was studied. Three experiments were performed, all using i.p. injections of saline, and of 75, 150 and 300 mg chloral hydrate/kg body wt. In the 1st experiment, body temperature was measured in a standard (23.degree. C) environment for 6 hr following injection. Rats were hypothermic following administration of the 150 and 300 mg/kg dosages for up to 1 and 2 h, respectively. In the 2nd experiment, FEP were recorded from the visual cortex of chronically implanted rats 30 min after injection (22.degree. C environment). P1N1, N1P2 and P2N2 amplitudes and P1, N1, P2, N2 and P3 peak latencies were significantly increased by the 300 mg/kg dosage. Increased latencies were also noted for the primary components with the 150 mg/kg dosage. The final experiment replicated the 2nd experiment, but at an ambient temperature of 30.degree. C, which prevented hypothermia. Amplitudes were unaffected by chloral hydrate. Significantly increased peak latencies were observed, even with the 75 mg/kg dose for some components. The magnitude of the latency increases of the primary components was less than half of that found with a standard environment. Thus, depending upon ambient temperature, hypothermia may contribute to chloral hydrate-induced alterations in FEP.
