8-O-Azeloyl-14-benzoylaconine:: A new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities
8-O-Azeloyl-14-benzoylaconine:: A new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities
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DOI：
10.1016/j.bmc.2005.07.015
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发表时间：
2005-12-01
影响因子：
3.5
通讯作者：
Robert, J
中科院分区：
文献类型：
--
作者：
Chodoeva, A;Bosc, JJ;Robert, J
从吉尔吉斯斯坦毛茛科乌头（Aconitum karacolicum Rapcs）的根中分离得到了一种新的生物碱，该生物碱基于其体外培养对三种人类肿瘤细胞系的抗增殖特性，采用了一种纯化方案。采用高分辨率MS-MS质谱和H-1， C-13, 2D NOESY NMR谱分析进行结构鉴定。该化合物由14-苯甲酰aconine部分在C-8上被一个偶氮基链取代。体外细胞毒性，IC50约为10-20 μ M，值得进一步研究其在癌症化疗中的潜在价值。(c) 2005 Elsevier Ltd版权所有。
A new alkaloid of Aconitum karacolicum Rapcs, from the Ranunculaceae family, collected in Kirghizstan, was isolated from the roots of this plant, using a purification scheme based upon its in vitro antiproliferative properties against three human tumour cell lines in culture. Structural identification was performed using high resolution MS-MS mass spectrometry and H-1, C-13, 2D NOESY NMR spectroscopy analysis. This compound consists of a 14-benzoylaconine moiety substituted on C-8 by an azeloyl chain. It presents in vitro cytotoxicity with an IC50 of about 10-20 mu M, which warrants further investigation on its possible interest in cancer chemotherapy. (c) 2005 Elsevier Ltd. All rights reserved.