NIGRAL DOPAMINE NEURONS - INTRACELLULAR-RECORDING AND IDENTIFICATION WITH L-DOPA INJECTION AND HISTOFLUORESCENCE
NIGRAL DOPAMINE NEURONS - INTRACELLULAR-RECORDING AND IDENTIFICATION WITH L-DOPA INJECTION AND HISTOFLUORESCENCE
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DOI：
10.1126/science.7433992
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发表时间：
1980-01-01
期刊：
影响因子：
56.9
通讯作者：
BUNNEY, BS
中科院分区：
文献类型：
--
作者：
GRACE, AA;BUNNEY, BS
对大鼠黑质含多巴胺神经元进行了体内细胞内记录。这些神经元分别通过电生理和左旋多巴注射以及随后的荧光组织化学鉴定。神经元的细胞外尖峰和反向传导速度与先前描述的多巴胺能神经元相同。观察到细胞内自发的快速电位、脉冲放电时的缓慢去极化和尖峰前电位。
Intracellular recordings in vivo were obtained for dopamine-containing neurons of the rat substantia nigra. These neurons were identified electrophysiologically by antidromic activation, and histochemically by L-dopa injection and subsequent fluorescence histochemistry. Extracellular spikes and antidromic conduction velocity of the neurons were identical to those previously described for putative dopaminergic neurons. Spontaneous intracellular fast potentials, slow depolarizations during burst firing and spike prepotentials were observed.