Modulation of rat cardiac sodium channel by the stimulatory G protein α subunit
Modulation of rat cardiac sodium channel by the stimulatory G protein α subunit
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DOI：
10.1111/j.1469-7793.1999.0371p.x
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发表时间：
1999-07-15
影响因子：
5.5
通讯作者：
Shibata, EF
中科院分区：
文献类型：
--
作者：
Lu, T;Lee, HC;Shibata, EF
1.用膜片钳技术研究了G蛋白刺激性α亚基(Gsα)对新分离的大鼠心肌细胞钠电流(I-Na)的调节作用。全细胞记录显示，10 mU异丙肾上腺素(ISO)刺激β-肾上腺素能受体，使[I-Na]升高68.4+/-9.6%(Mean+/-S.E.M.；n=7，P
1. Modulation of cardiac sodium currents (I-Na) by the G protein stimulatory alpha subunit (Gs alpha) was studied using patch-clamp techniques on freshly dissociated rat ventricular myocytes.2. Whole-cell recordings showed that stimulation of beta-adrenergic receptors with 10 mu M isoprenaline (isoproterenol, ISO) enhanced I-Na by 68.4 +/- 9.6% (mean +/- S.E.M.; n = 7, P