Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions
Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions
复制标题
DOI：
10.1177/0333102416651454
复制
发表时间：
2017-05-01
期刊：
影响因子：
4.9
通讯作者：
Pfund, Zoltan
中科院分区：
文献类型：
--
作者：
Erdelyi-Botor, Szilvia;Komaromy, Hedvig;Pfund, Zoltan
背景/目的：偏头痛是形成无症状脑白色病变（WML）的危险因素，其本质上可能是缺血性的。虽然L-精氨酸/一氧化氮（NO）通路的功能障碍与偏头痛中的氧化应激和内皮功能障碍有关，但其在WML发展中的作用尚未得到专门研究。因此，这项前瞻性研究的目的是测量血清浓度的NO底物L-精氨酸，NO合成酶抑制剂不对称二甲基精氨酸（ADMA），和L-精氨酸转运调节剂对称二甲基精氨酸（SDMA）在偏头痛患者在一个头痛免费periods.Methods：所有参与者进行了磁共振成像，以评估液体衰减反转恢复成像的存在WMLs。共109名偏头痛患者（43名病变，66名无病变）和46名对照组进行了研究。高效液相色谱法用于定量L-精氨酸，ADMA和SDMA血清浓度。偏头痛的特点进行了调查，参与者进行了筛选的危险因素，可以导致独立的偏头痛血清ADMA水平升高。结果：偏头痛患者和对照组在血管危险因素方面没有差异。偏头痛患者WML的病程较长（p
Background/Aim: Migraine is a risk factor for the formation of silent brain white matter lesions (WMLs) that are possibly ischemic in nature. Although dysfunction of the L-arginine/nitric oxide (NO) pathway has been associated with oxidative stress and endothelial dysfunction in migraine, its role in WML development has not been specifically investigated. Thus, this prospective study aimed to measure the serum concentrations of the NO substrate L-arginine, the NO synthase inhibitor asymmetric dimethylarginine (ADMA), and the L-arginine transport regulator symmetric dimethylarginine (SDMA) in migraine patients in a headache-free period.Methods: All participants underwent MR imaging to assess for the presence of WMLs on fluid-attenuated inversion recovery imaging. Altogether 109 migraine patients (43 with lesions, 66 without lesions) and 46 control individuals were studied. High-performance liquid chromatography was used to quantify L-arginine, ADMA and SDMA serum concentrations. Migraine characteristics were investigated, and participants were screened for risk factors that can lead to elevated serum ADMA levels independent of migraine.Results: Migraine patients and controls did not differ in regard to vascular risk factors. Migraineurs with WMLs had a longer disease duration (p