Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital
Basic and clinical research on photodynamic therapy at Tokyo Medical University Hospital
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DOI：
10.1002/lsm.20346
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发表时间：
2006-06-01
影响因子：
2.4
通讯作者：
Tsuitsui, H.
中科院分区：
文献类型：
--
作者：
Kato, H.;Usuda, J.;Tsuitsui, H.
背景和目标：我们一直从事光动力学治疗（PDT）和光动力学诊断（PDD）的基础和临床研究超过25 years.Study Design/Materials and Methods：PDT治疗264个中心位于早期肺癌病灶产生了84.8%的初始完全缓解（CR）率。PDT现在正成为中心定位0期（TisNOMO）和I期（T1 NOMO）肺癌的标准选择。这是一个有吸引力的选择，为老年患者在身体条件差。结果：最近的结果间质PDT周围型肺癌表明，它可能是一个有前途的局部治愈性治疗方式病变直径小于1.0厘米。结论：本文介绍了光动力疗法治疗肺癌的临床研究进展（包括中心和外周），以及PDD在乳腺癌前哨淋巴结导航活检中的新技术。此外，我们还介绍了肿瘤和感染性疾病的基础研究，以扩大PDT的临床应用。
Background and Objectives: We have been engaged in basic and clinical research on photodynamic therapy (PDT) and photodynamic diagnosis (PDD) for more than 25 years.Study Design/Materials and Methods: PDT for 264 centrally located early-stage lung cancer lesions yielded an initial complete response (CR) rate of 84.8%. PDT is now becoming a standard option for centrally located stage 0 (TisNOMO) and stage I (T1NOMO) lung cancer. It is an attractive option for elderly patients in poor physical condition.Results: Recent results of interstitial PDT for peripheral-type lung cancers suggest that it may be a promising local curative treatment modality for lesions less than 1.0 cm in diameter.Conclusions: In this article, we introduce our recent clinical trials of PDT for lung cancers (both central and peripheral), and new techniques of PDD in sentinel node navigation biopsy for breast cancers. Moreover, we introduce basic research on cancers and infectious diseases in order to expand the clinical applications of PDT.