Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research
Knowledge and attitude regarding pharmacogenetics among formerly pregnant women in the Netherlands and their interest in pharmacogenetic research
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DOI：
10.1186/s12884-017-1290-z
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发表时间：
2017-04-14
影响因子：
3.1
通讯作者：
Wilffert, Bob
中科院分区：
文献类型：
--
作者：
Daud, Aizati N. A.;Bergsma, Eefke L.;Wilffert, Bob
背景：药物遗传学是一个新兴的领域，目前正在实施，以提高处方时的安全性。虽然许多在怀孕期间服用药物的妇女可能会从这种个性化药物治疗中受益，但缺乏关于妇女对药物遗传学认识的数据。我们的目标是确定荷兰前孕妇对药物遗传学及其实施的知识和接受程度，以及她们对药物遗传学研究的兴趣。方法：在荷兰北部地区的前孕妇中进行了一项以人口为基础的邮政问卷调查。共有986名妇女被邀请参加。结果：219名已完成问卷调查的女性中，仅有22.8%的人听说过药物遗传学，而大多数女性（64.8%）了解药物遗传学的概念。经历过药物副作用的女性更有可能了解药物遗传学[OR = 2.06, 95% CI 1.16, 3.65]。53.9%的受访者对在未来的药物治疗中应用药物遗传学持积极态度，46.6%的受访者愿意参与药物遗传学研究。在那些不愿意或在这方面犹豫不决的人中，他们担心的是药物遗传学测试的后果，包括他们遗传信息的隐私和匿名性。结论：关注人群对药物遗传学概念的认识和态度较好。此外，他们对药物遗传学研究的兴趣为未来有关怀孕期间药物使用和胎儿结局的研究提供了机会。
Background: Pharmacogenetics is an emerging field currently being implemented to improve safety when prescribing drugs. While many women who take drugs during pregnancy would likely benefit from such personalized drug therapy, data is lacking on the awareness towards pharmacogenetics among women. We aim to determine the level of knowledge and acceptance of formerly pregnant women in the Netherlands regarding pharmacogenetics and its implementation, and their interest in pharmacogenetic research.Methods: A population-based survey using postal questionnaires was conducted among formerly pregnant women in the Northern parts of the Netherlands. A total of 986 women were invited to participate.Results: Of the 219 women who returned completed questionnaires (22.2% response rate), only 22.8% had heard of pharmacogenetics, although the majority understood the concept (64.8%). Women who had experience with drug side-effects were more likely to know about pharmacogenetics [OR = 2.06, 95% CI 1.16, 3.65]. Of the respondents, 53.9% were positive towards implementing pharmacogenetics in their future drug therapy, while 46.6% would be willing to participate in pharmacogenetic research. Among those who were either not willing or undecided in this regard, their concerns were about the consequences of the pharmacogenetic test, including the privacy and anonymity of their genetic information.Conclusion: The knowledge and attitude regarding the concept of pharmacogenetics among our population of interest is good. Also, their interest in pharmacogenetic research provides opportunities for future research related to drug use during pregnancy and fetal outcome.