Growth and development in term infants fed long-chain polyunsaturated fatty acids: A double-masked, randomized, parallel, prospective, multivariate study
Growth and development in term infants fed long-chain polyunsaturated fatty acids: A double-masked, randomized, parallel, prospective, multivariate study
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DOI：
10.1542/peds.108.2.372
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发表时间：
2001-08-01
期刊：
影响因子：
8
通讯作者：
Bornstein, MH
中科院分区：
文献类型：
--
作者：
Auestad, N;Halter, R;Bornstein, MH
目标。[目的]评价膳食摄入长链多不饱和脂肪酸、花生四烯酸(AA)和二十二碳六烯酸(DHA)对婴儿生长发育多项指标的影响。一项双盲、随机、平行试验对足月儿进行了为期一年的添加或不添加AA+DHA配方奶粉的研究(N=239)。同时还研究了母乳喂养的婴儿(N=165)，断奶时添加和不添加AA+DHA的配方奶。配方奶粉组的婴儿在小于或等于9日龄时被随机分配到不含AA或DHA的对照组配方奶粉(n=77)，或两个其他相同的配方奶粉中的一个(AA+DHA，AA，0.46%和DHA，占总脂肪酸的0.14%)，来自鸡蛋来源的甘油三酯(鸡蛋-DTG[n=80])或鱼油和真菌油(鱼/真菌油[n=82])，水平与参考组母乳样本中的平均水平相似。所有配方都含有50%来自脂肪的能量，以及必需的膳食脂肪酸亚油酸(20%脂肪酸)和α-亚麻酸(2%脂肪酸)。主要研究结果是血浆和红细胞中AA和DHA水平，以及从出生到14个月的多项婴儿发育指标：生长、视力、信息处理、一般发育、语言和气质。AA+DHA补充组血浆和红细胞中AA和DHA水平均高于对照组，与参照组相近。没有发育测试结果区分这些群体。与母乳喂养相关的家庭人口学方面的预期差异被发现，但在所显示的任何发育结果上母乳喂养都没有优势。这些发现不支持将AA+DHA添加到含有10%能量(亚油酸)和1%能量(α-亚麻酸)的配方中，以在出生后14个月内促进健康足月儿的生长、视力、信息处理、一般发育、语言或气质。
Objective. To evaluate the effects of dietary intake of the long-chain polyunsaturated fatty acids, arachidonic acid (AA), and docosahexaenoic acid (DHA) on multiple indices of infant growth and development.Design. A double-masked, randomized, parallel trial was conducted with term infants fed formulas with or without AA+DHA for 1 year (N = 239). Reference groups of breastfed infants (N = 165) weaned to formulas with and without AA+DHA were also studied. Infants in the formula groups were randomized at less than or equal to9 days of age to a control formula with no AA or DHA (n = 77) or 1 of 2 otherwise identical formulas containing AA+DHA (AA, 0.46% and DHA, 0.14% of total fatty acids) from either egg-derived triglyceride (egg-DTG [n=80]) or fish oil and fungal oil (fish/fungal [n = 82]) at levels similar to the average in breast milk samples as measured in the reference group. All formulas contained 50% of energy from fat with the essential dietary fatty acids, linoleic acid (20% fatty acids) and alpha -linolenic acid (2% fatty acids). The main study outcomes were AA and DHA levels in plasma and red blood cells, and multiple measures of infant development at multiple ages from birth to 14 months: growth, visual acuity, information processing, general development, language, and temperament.Results. AA and DHA levels in plasma and red cells were higher in AA+DHA-supplemented groups than in the control formula group and comparable to those in reference groups. No developmental test results distinguished these groups. Expected differences in family demographics associated with breastfeeding were found, but no advantages to breastfeeding on any of the developmental outcome demonstrated.Conclusions. These findings do not support adding AA+DHA to formulas containing 10% energy as linoleic acid and 1% energy as alpha -linolenic acid to enhance growth, visual acuity, information processing, general development, language, or temperament in healthy, term infants during the first 14 months after birth.