Conversion of Androgen to Estrogen and Other Steroids in the Vertebrate Brain
Conversion of Androgen to Estrogen and Other Steroids in the Vertebrate Brain
复制标题
脊椎动物大脑中雄激素转化为雌激素和其他类固醇
DOI：
--
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
K. Ryan
中科院分区：
文献类型：
--
作者：
G. Callard;Z. Petro;K. Ryan
芳香化酶活性已被检测到在中枢神经系统（CNS）的每个主要的脊椎动物组的代表与无颌。5 α-还原酶和17/3-氧化还原酶也存在于许多脊椎动物的脑组织和龙虾的脑神经节中。这些比较研究与哺乳动物和选定的非哺乳动物物种的放射自显影，生理和行为数据支持的观点，即原位代谢是雄激素作用的重要组成部分和脊椎动物大脑的一般特征。
Aromatase activity has been detected in the central nervous system (CNS) of representatives of each major vertebrate group with the exception of the Agnatha. 5a-reductase and 17/3-oxidoreductase are also present in brain tissues of many vertebrates and in the cerebral ganglion of the lobster. These comparative studies together with autoradiographic, physiological, and behavioral data in mammals and selected nonmammalian species support the view that metabolism in situ is an important component of androgen action and a general characteristic of the vertebrate brain.