Quantitative effects of the peripheral innervation area on nerves and spinal ganglion cells
Quantitative effects of the peripheral innervation area on nerves and spinal ganglion cells
复制标题
周围神经支配区域对神经和脊神经节细胞的定量影响
DOI：
10.1002/cne.900940203
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发表时间：
1951
影响因子：
2.5
通讯作者：
M. Cavanaugh
中科院分区：
文献类型：
--
作者：
M. Cavanaugh
在最近关于神经纤维再生的研究中（韦斯和泰勒，1944），注意到在切断和分开的神经中，一半的纤维被阻塞并且不允许进行末端连接，而另一半被允许无阻碍地再生，在未连接的分支中的神经纤维没有达到与再生的连接的纤维相当的尺寸。Sanders和Young进一步研究了永久断开的神经（1945，1946），韦斯，Edds和Cavanaugh（1945）和Aitken，Sharman和Young（1947）在成年家兔和大鼠中进行了研究，发现神经纤维可以达到的尺寸，虽然受到允许其再生的管的直径的限制（Sanders和Young，1944年;哈蒙德和Hinsey，1945年; Simpson和Young，1945年）在很大程度上取决于连接是否与终末器官发生作用。因此，有人认为，如果神经纤维不能到达肌肉、皮肤等并与之建立功能性联系，它就缺乏恢复其原有状态所必需的条件。在十九世纪末和二十世纪初，（即简单切片、撕脱、离起源细胞不同距离的切片和切除不同数量的神经）
During recent studies on regeneration of nerve fibers (Weiss and Taylor, 1944), it was noted that in a nerve transected and divided so that one-half of the fibers was bloc ke d and not allowed to make terminal connec tions, while the other half was per-mitted to regenerate unimpeded, the nerve fibers in the unconnec ted branch did not attain a size comparable to the regenerated, connec ted fibers. Permanently disconnected nerves were further studied by Sanders and Young (1945, 1946), Weiss, Edds and Cavanaugh (1945) and Aitken, Sharman and Young (1947) in adult rabbits and rats, and it was found that the size which a nerve fiber could attain, while somewhat limited by the diameter of the tube into which it was allowed to regenerate (Sanders and Young, l944; Hammond and Hinsey, 1945; Simpson and Young, 1945) was for the most part de termined by whether or not a connection was effected with an end organ. Therefore it was sugge sted that if a nerve fiber were unable to reach and make a functional connec-tion with muscle, skin, etc, it was lacking in a condition nec essary to permit return to its former state, During the last part of the nine teenth and beginning of the twentieth century, investigators concerned with cases of limb amputation or with various types of nerve section (ie, simple section, evulsion, section at varying distances from the cells of origin and resec tion of various amounts of nerve) frequently l