Biocatalytic derivatization of proteinogenic amino acids for fine chemicals.
Biocatalytic derivatization of proteinogenic amino acids for fine chemicals.
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DOI：
10.1016/j.biotechadv.2019.107496
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发表时间：
2019-11
影响因子：
16
通讯作者：
Wei Song;Xiulai Chen;Jing Wu;Jian-zhong Xu;Weiguo Zhang;Jia Liu;Jian Chen;Liming Liu
中科院分区：
文献类型：
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作者：
Wei Song;Xiulai Chen;Jing Wu;Jian-zhong Xu;Weiguo Zhang;Jia Liu;Jian Chen;Liming Liu
氨基酸（AA）含有各种官能团，包括α-氨基、α-羧基和某些特定侧链，具有广泛的化学性质。通过生物催化对 AA 的这些官能团进行衍生化是生产各种化学品的可持续方法，例如 α-酮酸、α-羟基酸、非蛋白氨基酸、胺、肽、高级醇和苯丙素，这些化学品在制药、化学合成、化妆品和食品工业中具有重要价值。在这里，我们回顾了AA衍生化的最新进展，描述了衍生化反应的设计、如何克服技术瓶颈以及可能获得的化学品的潜在范围。此外，我们还强调了未来的前景并解决了用于精细化学品生产的 AA 衍生化中仍然存在的挑战。
Amino acids (AAs), which contain various functional groups including α-amino group, α-carboxyl group, and certain specific side-chains, exhibit a wide range of chemical properties. The derivatization of these functional groups of AAs via biocatalysis represents a sustainable approach for producing various chemicals, such as α-keto acids, α-hydroxyl acids, non-proteinogenic AAs, amines, peptides, higher alcohols, and phenylpropanoids, that are valuable in the pharmaceutical, chemical synthesis, cosmetic, and food industries. Here, we review recent advances in the derivatization of AAs to describe the design of derivatization reactions, how to overcome technical bottlenecks, and the potential range of chemicals that may be obtained. Furthermore, we highlight future prospects and address the challenges that remain in the derivatization of AAs for the production of fine chemicals.