Observation of Singlet Oxygen with Single-Molecule Photosensitization by Time-Dependent Photon Statistics
Observation of Singlet Oxygen with Single-Molecule Photosensitization by Time-Dependent Photon Statistics
复制标题
通过时间依赖性光子统计观察单分子光敏化的单线态氧
DOI：
10.1021/acs.jpclett.8b02088
复制
发表时间：
2018-09-20
影响因子：
5.7
通讯作者：
Jia, Suotang
中科院分区：
文献类型：
--
作者：
Li, Yao;Chen, Ruiyun;Jia, Suotang
单线态氧已广泛应用于生理疾病的治疗，而光敏化产生单线态氧是其生理应用的主要手段。在单光敏剂荧光场涨落的基础上，用含时光子统计方法在单分子水平上表征了单线态氧的产生。通过测量单分子荧光的时间分辨光子，分析了不同氧环境下的Mandel-Q参数随时间的变化。结果表明，单分子不仅提供了一种有效的方式产生单线态氧在环境条件下，但也提供了见解单线态氧在纳米环境中的波动。含时光子统计方法为在单光敏剂水平上真实的实时观察光敏剂产生单线态氧提供了一种方便的方法。
The singlet oxygen has been widely applied to the treatment of physiological diseases, and the photosensitized generation of singlet oxygen is the main means of its physiological applications. On the basis of the fluctuation of fluorescence field from single photosensitizer, we characterize the generation of singlet oxygen at single molecule level with the time-dependent photon statistical method. By measuring the timetagged-time-resolved single-molecule fluorescence photons, we analyze the time-dependent Mandel-Q parameter, which has been performed at different oxygen environment. It is shown that the single molecule not only offers an efficient way of generating singlet oxygen in ambient condition but also provides insights for the fluctuation of singlet oxygen in the nanoscale environment. The method of time-dependent photon statistics provides a convenient methodology for observing photosensitizers generating singlet oxygen in real time at single photosensitizer level.